Sensing cellular stress: another new function for the nucleolus?

Recent research suggests that the nucleolus communicates with the p53 regulatory system and acts as a stress sensor. Cellular stress causes nucleolar disruption, triggering the release of regulatory factors to the nucleoplasm. These factors, especially ARF (alternative reading frame), inhibit the de...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science's signal transduction knowledge environment (STKE) 2004-03, Vol.2004 (224), p.pe10-pe10
1. Verfasser:	Olson, Mark O J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Nucleolus - physiology Cyclin-Dependent Kinase Inhibitor p16 Gene Expression Regulation - physiology Genes, p53 Humans Models, Biological Nuclear Proteins Protein Processing, Post-Translational Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-mdm2 Stress, Physiological - physiopathology Tumor Suppressor Protein p14ARF - physiology Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - physiology Ubiquitin - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Recent research suggests that the nucleolus communicates with the p53 regulatory system and acts as a stress sensor. Cellular stress causes nucleolar disruption, triggering the release of regulatory factors to the nucleoplasm. These factors, especially ARF (alternative reading frame), inhibit the degradation of p53, thereby facilitating its intracellular accumulation.
ISSN:	1525-8882 1525-8882
DOI:	10.1126/stke.2242004pe10