Diagnostic Value of Plasma Cystatin C as a Glomerular Filtration Marker in Decompensated Liver Cirrhosis

Plasma creatinine concentration and calculated creatinine clearance are of limited value as glomerular filtration rate (GFR) markers in patients with decompensated liver cirrhosis. We assessed plasma cystatin C as an indicator of GFR in such patients. We studied 36 patients with decompensated liver...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2002-06, Vol.48 (6), p.850-858
Hauptverfasser:	Orlando, Rocco, Mussap, Michele, Plebani, Mario, Piccoli, Pierpaolo, De Martin, Sara, Floreani, Maura, Padrini, Roberto, Palatini, Pietro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers - blood Cross-Sectional Studies Cystatin C Cystatins - blood Glomerular Filtration Rate Humans Immunoassay Investigative techniques, diagnostic techniques (general aspects) Liver Cirrhosis - blood Liver Cirrhosis - diagnosis Liver Cirrhosis - urine Male Medical sciences Middle Aged Miscellaneous. Technology Nephelometry and Turbidimetry Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
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Zusammenfassung:	Plasma creatinine concentration and calculated creatinine clearance are of limited value as glomerular filtration rate (GFR) markers in patients with decompensated liver cirrhosis. We assessed plasma cystatin C as an indicator of GFR in such patients. We studied 36 patients with decompensated liver cirrhosis and 56 noncirrhotic controls, both groups including individuals with normal and impaired renal function. GFR was measured in all individuals by inulin clearance, with values
ISSN:	0009-9147 1530-8561
DOI:	10.1093/clinchem/48.6.850