Systemic radioimmunotherapy using a monoclonal antibody, anti-Tac directed toward the alpha subunit of the IL-2 receptor armed with the alpha-emitting radionuclides (212)Bi or (211)At

Systemic radioimmunotherapy using a monoclonal antibody, anti-Tac directed toward the alpha subunit of the IL-2 receptor armed with the alpha-emitting radionuclides (212)Bi or (211)At

To exploit the fact that IL-2 receptors are expressed by T-cells responding to foreign antigens but not by resting T-cells, humanized anti-Tac (HAT) armed with alpha-emitting radionuclides (212)Bi and (211)At was evaluated in a cynomolgus cardiac allograft model. Control graft survival was 8.2+/- 0....

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nuclear medicine and biology 2004-04, Vol.31 (3), p.357-364
Hauptverfasser: Wesley, Jon N, McGee, Edwin C, Garmestani, Kayhan, Brechbiel, Martin W, Yordanov, Alexander T, Wu, Chuanchu, Gansow, Otto A, Eckelman, William C, Bacher, John D, Flynn, Michael, Goldman, Carolyn K, MacLin, Melvin, Schwartz, Uwe P, Jackson-White, Terri, Phillip, Celeste M, Decker, Jean, Waldmann, Thomas A
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antibodies, Monoclonal - immunology
Antibodies, Monoclonal - therapeutic use
Astatine - immunology
Astatine - therapeutic use
Bismuth - immunology
Bismuth - therapeutic use
Female
Graft Rejection - immunology
Graft Rejection - prevention & control
Graft Rejection - radiotherapy
Graft Survival - immunology
Macaca fascicularis
Mice
Mice, Nude
Protein Subunits
Radioimmunotherapy - methods
Radioisotopes - therapeutic use
Radiopharmaceuticals - immunology
Radiopharmaceuticals - therapeutic use
Receptors, Interleukin-2 - immunology
Treatment Outcome
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:To exploit the fact that IL-2 receptors are expressed by T-cells responding to foreign antigens but not by resting T-cells, humanized anti-Tac (HAT) armed with alpha-emitting radionuclides (212)Bi and (211)At was evaluated in a cynomolgus cardiac allograft model. Control graft survival was 8.2+/- 0.5 days compared with 14.0+/-1.3 days (p
ISSN:0969-8051
DOI:10.1016/j.nucmedbio.2003.08.011