Doxorubicin prodrug on the basis of tert-butyl cephalosporanate sulfones

Doxorubicin-cephalosporin prodrug adapted to the development of elastases for the liberation of parent drug was synthesized on the basis of cephalosporanate sulfone esters.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2004-02, Vol.14 (4), p.1007-1010
Hauptverfasser:	VEINBERG, Grigory, SHESTAKOVA, Irina, VORONA, Maxim, KANEPE, Iveta, DOMRACHOVA, Ilona, LUKEVICS, Edmunds
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cell Line, Tumor Cell Survival - drug effects Cephalosporins - chemical synthesis Cephalosporins - pharmacology Chemotherapy Doxorubicin - chemical synthesis Doxorubicin - pharmacology Drug Design Esters - chemical synthesis Esters - pharmacology Humans Medical sciences Mice Molecular Structure Pancreatic Elastase - antagonists & inhibitors Pharmacology. Drug treatments Prodrugs - chemical synthesis Prodrugs - pharmacology Sulfones - chemical synthesis Sulfones - pharmacology
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Beschreibung
Zusammenfassung:	Doxorubicin-cephalosporin prodrug adapted to the development of elastases for the liberation of parent drug was synthesized on the basis of cephalosporanate sulfone esters.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2003.11.071