Expanded Scope in Ethylene−Alkyne Cross-Metathesis: Coordinating Heteroatom Functionality at the Propargylic Position

The Grubbs 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene-substituted ruthenium complex 1 catalyzed ethylene−alkyne cross-metathesis and was shown to tolerate free hydroxyl groups and coordinating functionality at the propargylic and homopropargylic positions. Hindered and enantiomerically enriched 1-s...

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Veröffentlicht in:	Organic letters 2000-07, Vol.2 (15), p.2271-2274
Hauptverfasser:	Smulik, Jason A, Diver, Steven T
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Alkynes - metabolism Catalysis Chelating Agents - metabolism Ethylenes - chemistry Ethylenes - metabolism Kinetics Ruthenium Compounds - chemistry Ruthenium Compounds - metabolism Stereoisomerism
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description	The Grubbs 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene-substituted ruthenium complex 1 catalyzed ethylene−alkyne cross-metathesis and was shown to tolerate free hydroxyl groups and coordinating functionality at the propargylic and homopropargylic positions. Hindered and enantiomerically enriched 1-substituted alkynes also react efficiently under the reported conditions.
doi_str_mv	10.1021/ol006035l
format	Article
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subjects	Alkynes - chemistry Alkynes - metabolism Catalysis Chelating Agents - metabolism Ethylenes - chemistry Ethylenes - metabolism Kinetics Ruthenium Compounds - chemistry Ruthenium Compounds - metabolism Stereoisomerism
title	Expanded Scope in Ethylene−Alkyne Cross-Metathesis: Coordinating Heteroatom Functionality at the Propargylic Position
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