Expanded Scope in Ethylene−Alkyne Cross-Metathesis:  Coordinating Heteroatom Functionality at the Propargylic Position

Expanded Scope in Ethylene−Alkyne Cross-Metathesis:  Coordinating Heteroatom Functionality at the Propargylic Position

The Grubbs 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene-substituted ruthenium complex 1 catalyzed ethylene−alkyne cross-metathesis and was shown to tolerate free hydroxyl groups and coordinating functionality at the propargylic and homopropargylic positions. Hindered and enantiomerically enriched 1-s...

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Veröffentlicht in:Organic letters 2000-07, Vol.2 (15), p.2271-2274
Hauptverfasser: Smulik, Jason A, Diver, Steven T
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes - chemistry
Alkynes - metabolism
Catalysis
Chelating Agents - metabolism
Ethylenes - chemistry
Ethylenes - metabolism
Kinetics
Ruthenium Compounds - chemistry
Ruthenium Compounds - metabolism
Stereoisomerism
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Zusammenfassung:The Grubbs 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene-substituted ruthenium complex 1 catalyzed ethylene−alkyne cross-metathesis and was shown to tolerate free hydroxyl groups and coordinating functionality at the propargylic and homopropargylic positions. Hindered and enantiomerically enriched 1-substituted alkynes also react efficiently under the reported conditions.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol006035l