Solid-phase synthesis of an arylsulfone hydroxamate library

Synthesis of an arylsulfone hydroxamate lead optimization library is presented. Biological activity of representative examples is given to demonstrate the value of this approach for lead optimization.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2000-08, Vol.10 (15), p.1637-1640
Hauptverfasser:	Salvino, Joseph M, Mathew, Rose, Kiesow, Terence, Narensingh, Ramesh, Mason, Helen J, Dodd, Amy, Groneberg, Robert, Burns, Christopher J, McGeehan, Gerald, Kline, Jane, Orton, Edward, Tang, Sheng-Yuh, Morrisette, Mathew, Labaudininiere, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors Biological and medical sciences Cyclic Nucleotide Phosphodiesterases, Type 4 Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology General pharmacology Hydroxamic Acids - chemical synthesis Hydroxamic Acids - chemistry Hydroxamic Acids - pharmacology Matrix Metalloproteinase Inhibitors Medical sciences Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Structure-Activity Relationship Sulfones - chemistry
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Beschreibung
Zusammenfassung:	Synthesis of an arylsulfone hydroxamate lead optimization library is presented. Biological activity of representative examples is given to demonstrate the value of this approach for lead optimization.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(00)00285-7