Immunocytochemical study of the dorsal and median raphe nuclei in patients with Alzheimer's disease prospectively assessed for behavioural changes

The dorsal and median raphe nuclei were examined with immunocytochemistry to display the 5‐HT neurones in 16 cases of post‐mortem‐proven Alzheimer’s disease (AD) and 12 age and sex‐matched controls. The AD cases had been prospectively assessed during life for expression of behavioural changes as wel...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuropathology and applied neurobiology 2000-08, Vol.26 (4), p.347-355
Hauptverfasser:	Chen, C. P. L. -H., Eastwood, S. L., Hope, T., McDonald, B., Francis, P. T., Esiri, M. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease Amyloid beta-Protein Precursor - metabolism Behavioral Symptoms - etiology Behavioral Symptoms - physiopathology behavioural changes Biological and medical sciences Cell Count Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Humans immunocytochemistry Immunohistochemistry Male Medical sciences Neurology Neurons - metabolism Neurons - pathology neuropathology Neuropil - metabolism Neuropil - pathology Plaque, Amyloid - metabolism Plaque, Amyloid - pathology Prospective Studies raphe nuclei Raphe Nuclei - metabolism Raphe Nuclei - pathology serotonin tau Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The dorsal and median raphe nuclei were examined with immunocytochemistry to display the 5‐HT neurones in 16 cases of post‐mortem‐proven Alzheimer’s disease (AD) and 12 age and sex‐matched controls. The AD cases had been prospectively assessed during life for expression of behavioural changes as well as for cognitive decline. A significant (P
ISSN:	0305-1846 1365-2990
DOI:	10.1046/j.1365-2990.2000.00254.x