99mTc-N, N′-bis(aminoethyl)propanediamine hexaacetic acid (BPHA): a glomerular filtration agent similar to 99mTc-DTPA
Investigations on the biodistribution of 99mTc-BPHA in normal and probenecid treated mice and a comparison with 99mTc-DTPA injected mice suggested that 99mTc-BPHA is also a glomerular filtration agent. Whole body radioactivity measurements in mice and rabbits after administration of 99mTc-BPHA showe...
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| Veröffentlicht in: | Nuclear medicine and biology 2002-05, Vol.29 (4), p.399-404 |
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| container_title | Nuclear medicine and biology |
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| creator | Liu, Guozheng Zhang, Chunli Liu, Fei Wang, Rongfu Fu, Zhanli Li, Guiqun Miao, Zengxing |
| description | Investigations on the biodistribution of
99mTc-BPHA in normal and probenecid treated mice and a comparison with
99mTc-DTPA injected mice suggested that
99mTc-BPHA is also a glomerular filtration agent. Whole body radioactivity measurements in mice and rabbits after administration of
99mTc-BPHA showed negligible whole body radioactivity at 24 h. Excellent kidney images both in rabbits and a human volunteer were obtained. The significance of higher GFR estimates using
99mTc-BPHA compared to
99mTc-DTPA is discussed. |
| doi_str_mv | 10.1016/S0969-8051(02)00302-5 |
| format | Article |
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99mTc-BPHA compared to
99mTc-DTPA is discussed.</description><subject>Acetates - pharmacokinetics</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Glomerular filtration</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Imaging</subject><subject>Kidney</subject><subject>Kidney - diagnostic imaging</subject><subject>Kidney - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Organometallic Compounds - pharmacokinetics</subject><subject>Polyamines - pharmacokinetics</subject><subject>Probenecid - administration & dosage</subject><subject>Rabbits</subject><subject>Radioisotope Renography - methods</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Reference Values</subject><subject>Sensitivity and Specificity</subject><subject>Technetium Compounds</subject><subject>Technetium Tc 99m Pentetate - pharmacokinetics</subject><subject>Technetium-99m</subject><subject>Tissue Distribution</subject><subject>Whole-Body Counting</subject><issn>0969-8051</issn><issn>1872-9614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkNtuEzEQhi0EoqHwCCDfUCUSC2Pv-sRNFcqhSFWpRLi2HO9sa7SHYG-gvesz8Ug8Cd4mopdIlkayv5nf8xHynMFrBky--QpGmkKDYHPgC4ASeCEekBnTihdGsuohmf1DDsiTlL5D7qsYPCYHjEOZwWpGfhnTrXxx_oqe_7n9XaxDmrsu9AOOVzftYhOHjeuxDtMd0iu8ds7jGDx1PtR0_u7idLl4Sx29bIcO47Z1kTahHaMbw9BTd4n9SFPowvQwDnQX9n51sXxKHjWuTfhsXw_Jt48fVienxdmXT59PlmeFZ1pWhVhrVKDzKQ2UHFA7lJpLo2ujq8aIRnImHNZK1IorrgXotfLaeFOVzInykBzt5uZVfmwxjbYLyWPb5rWGbbKKKS4YlBkUO9DHIaWIjd3E0Ll4YxnYybi9M24nnRa4vTNup4AX-4DtusP6vmuvOAMv94BL3rVNdL0P6Z4rpdJSQeaOdxxmHT8DRpt8wN5n-xH9aOsh_OcrfwE_MJtA</recordid><startdate>200205</startdate><enddate>200205</enddate><creator>Liu, Guozheng</creator><creator>Zhang, Chunli</creator><creator>Liu, Fei</creator><creator>Wang, Rongfu</creator><creator>Fu, Zhanli</creator><creator>Li, Guiqun</creator><creator>Miao, Zengxing</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200205</creationdate><title>99mTc-N, N′-bis(aminoethyl)propanediamine hexaacetic acid (BPHA): a glomerular filtration agent similar to 99mTc-DTPA</title><author>Liu, Guozheng ; 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99mTc-BPHA in normal and probenecid treated mice and a comparison with
99mTc-DTPA injected mice suggested that
99mTc-BPHA is also a glomerular filtration agent. Whole body radioactivity measurements in mice and rabbits after administration of
99mTc-BPHA showed negligible whole body radioactivity at 24 h. Excellent kidney images both in rabbits and a human volunteer were obtained. The significance of higher GFR estimates using
99mTc-BPHA compared to
99mTc-DTPA is discussed.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>12031874</pmid><doi>10.1016/S0969-8051(02)00302-5</doi><tpages>6</tpages></addata></record> |
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| ispartof | Nuclear medicine and biology, 2002-05, Vol.29 (4), p.399-404 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acetates - pharmacokinetics Animals Biological and medical sciences Female Glomerular filtration Glomerular Filtration Rate Humans Imaging Kidney Kidney - diagnostic imaging Kidney - metabolism Male Medical sciences Mice Organometallic Compounds - pharmacokinetics Polyamines - pharmacokinetics Probenecid - administration & dosage Rabbits Radioisotope Renography - methods Radiopharmaceuticals - pharmacokinetics Reference Values Sensitivity and Specificity Technetium Compounds Technetium Tc 99m Pentetate - pharmacokinetics Technetium-99m Tissue Distribution Whole-Body Counting |
| title | 99mTc-N, N′-bis(aminoethyl)propanediamine hexaacetic acid (BPHA): a glomerular filtration agent similar to 99mTc-DTPA |
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