99mTc-N, N′-bis(aminoethyl)propanediamine hexaacetic acid (BPHA): a glomerular filtration agent similar to 99mTc-DTPA

Investigations on the biodistribution of 99mTc-BPHA in normal and probenecid treated mice and a comparison with 99mTc-DTPA injected mice suggested that 99mTc-BPHA is also a glomerular filtration agent. Whole body radioactivity measurements in mice and rabbits after administration of 99mTc-BPHA showe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nuclear medicine and biology 2002-05, Vol.29 (4), p.399-404
Hauptverfasser:	Liu, Guozheng, Zhang, Chunli, Liu, Fei, Wang, Rongfu, Fu, Zhanli, Li, Guiqun, Miao, Zengxing
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - pharmacokinetics Animals Biological and medical sciences Female Glomerular filtration Glomerular Filtration Rate Humans Imaging Kidney Kidney - diagnostic imaging Kidney - metabolism Male Medical sciences Mice Organometallic Compounds - pharmacokinetics Polyamines - pharmacokinetics Probenecid - administration & dosage Rabbits Radioisotope Renography - methods Radiopharmaceuticals - pharmacokinetics Reference Values Sensitivity and Specificity Technetium Compounds Technetium Tc 99m Pentetate - pharmacokinetics Technetium-99m Tissue Distribution Whole-Body Counting
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Investigations on the biodistribution of 99mTc-BPHA in normal and probenecid treated mice and a comparison with 99mTc-DTPA injected mice suggested that 99mTc-BPHA is also a glomerular filtration agent. Whole body radioactivity measurements in mice and rabbits after administration of 99mTc-BPHA showed negligible whole body radioactivity at 24 h. Excellent kidney images both in rabbits and a human volunteer were obtained. The significance of higher GFR estimates using 99mTc-BPHA compared to 99mTc-DTPA is discussed.
ISSN:	0969-8051 1872-9614
DOI:	10.1016/S0969-8051(02)00302-5