First Artificial Receptors and Chemosensors toward Phosphorylated Peptide in Aqueous Solution

The first fluorescent chemosensors toward a native phosphorylated peptide are successfully synthesized. Dinuclear zinc(II)-dipicolylamine-based anthracene (1, 2) can selectively recognize and sense phosphorylated species with an increase in the fluorescence intensity. We also demonstrated that these...

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Veröffentlicht in:	Journal of the American Chemical Society 2002-06, Vol.124 (22), p.6256-6258
Hauptverfasser:	Ojida, Akio, Mito-oka, Yasuko, Inoue, Masa-aki, Hamachi, Itaru
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemical synthesis Amines - chemistry Amino Acid Sequence Analytical chemistry Anthracenes - chemical synthesis Anthracenes - chemistry Biological and medical sciences Biosensors Biotechnology Chemistry Exact sciences and technology Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fundamental and applied biological sciences. Psychology General, instrumentation Methods. Procedures. Technologies Oligopeptides - chemistry Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Phosphopeptides - chemistry Phosphotyrosine - chemistry Receptors, Peptide - chemistry Solutions Spectrometry, Fluorescence Various methods and equipments Water - chemistry Zinc - chemistry
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Zusammenfassung:	The first fluorescent chemosensors toward a native phosphorylated peptide are successfully synthesized. Dinuclear zinc(II)-dipicolylamine-based anthracene (1, 2) can selectively recognize and sense phosphorylated species with an increase in the fluorescence intensity. We also demonstrated that these artificial receptors fluorometrically detect a phosphorylated peptide with high affinity (>107 M-1) in aqueous solution.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja025761b