Diterpenoids from the stem bark of Croton zambesicus

Three clerodane diterpenoids, crotozambefurans A, B and C were isolated from the stem bark of Croton zambesicus together with the known clerodane crotocorylifuran and two trachylobanes: 7β-acetoxytrachyloban-18-oic acid and trachyloban-7β, 18-diol. Betulinol, lupeol, sitosterol and its 3β-glucopyran...

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Veröffentlicht in:	Phytochemistry (Oxford) 2002-06, Vol.60 (4), p.345-349
Hauptverfasser:	Ngadjui, Bonaventure T, Abegaz, Berhanu M, Keumedjio, Felix, Folefoc, Gabriel N, Kapche, Gilbert W.F
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cameroon Chemical constitution Chromatography - methods Clerodane Croton - chemistry Croton zambesicus Crotozambefurans A, B and C Diterpenes - chemistry Euphorbiaceae Fundamental and applied biological sciences. Psychology Furans - chemistry Isolation Mass Spectrometry - methods Nuclear Magnetic Resonance, Biomolecular - methods Plant Bark - chemistry Plant Extracts - chemistry Plant physiology and development Plant Stems - chemistry Plants, Medicinal - chemistry Spectrometry, Mass, Electrospray Ionization Spectrophotometry, Infrared Stem bark Stereoisomerism
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Zusammenfassung:	Three clerodane diterpenoids, crotozambefurans A, B and C were isolated from the stem bark of Croton zambesicus together with the known clerodane crotocorylifuran and two trachylobanes: 7β-acetoxytrachyloban-18-oic acid and trachyloban-7β, 18-diol. Betulinol, lupeol, sitosterol and its 3β-glucopyranosyl derivative were also obtained. The structures of crotozambefurans A, B and C were determined, respectively, as: 15,16-epoxy-1,3,13(16),14-clerodatetraen-20,12-olide-18,19-dioic acid dimethylester, 15,16-epoxy-1,3,13(16),14-clerodatetraen-18,19,20-trioic acid trimethylester and 15,16-epoxy-3,13(16),14-clerodatrien-19,1α:20,12-diolide-18-oic acid methylester, using spectroscopic analysis, especially, NMR spectra in conjunction with 2D experiments, COSY, HSQC, HMBC and TOCSY. Three clerodane diterpenoids, one known, and two trachylobanes were identified from the stem bark of Croton zambesicus.
ISSN:	0031-9422 1873-3700
DOI:	10.1016/S0031-9422(02)00034-1