Chemical Synthesis of a Skeleton Structure of Sperm CD52-A GPI-Anchored Glycopeptide

Chemical Synthesis of a Skeleton Structure of Sperm CD52-A GPI-Anchored Glycopeptide

Going native: A highly convergent synthetic strategy was established to prepare a skeleton structure of sperm CD52 antigen (depicted), which represents the first chemical synthesis of a complex, all natively linked glycosylphosphatidylinositol (GPI)–glycopeptide conjugate.

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Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2004-03, Vol.43 (12), p.1569-1573
Hauptverfasser: Shao, Ning, Xue, Jie, Guo, Zhongwu
Format: Artikel
Sprache:eng
Schlagworte:
antigens
Antigens, CD - chemistry
Antigens, Neoplasm - chemistry
Carbohydrate Sequence
carbohydrates
CD52 Antigen
glycopeptides
Glycopeptides - chemical synthesis
Glycopeptides - chemistry
glycoproteins
Glycoproteins - chemical synthesis
Glycoproteins - chemistry
Glycosylphosphatidylinositols - chemical synthesis
Glycosylphosphatidylinositols - chemistry
Humans
Male
Molecular Sequence Data
Molecular Structure
solid-phase synthesis
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Beschreibung
Zusammenfassung:Going native: A highly convergent synthetic strategy was established to prepare a skeleton structure of sperm CD52 antigen (depicted), which represents the first chemical synthesis of a complex, all natively linked glycosylphosphatidylinositol (GPI)–glycopeptide conjugate.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200353251