Identification of a new mouse Cd1d2 allele

Summary The mouse CD1 system is formed by two closely related genes named Cd1d1 and Cd1d2. Cd1d1 encodes a molecule that presents antigens to NKT cells. The function of the Cd1d2 gene has not been elucidated. Here we described a method to analyse variations in mouse Cd1 genes. We found a new allele...

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Veröffentlicht in:	European journal of immunogenetics 2004-02, Vol.31 (1), p.1-3
Hauptverfasser:	Gozalbo-López, B., Pérez-Rosado, A., Parra-Cuadrado, J. F., Martínez-Naves, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - chemistry Alleles Amino Acid Sequence Animals Antigens, CD1 - genetics Antigens, CD1d Base Sequence Genetic Variation Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred NOD Molecular Sequence Data Point Mutation Polymerase Chain Reaction Polymorphism, Genetic Polymorphism, Single-Stranded Conformational Sequence Analysis, DNA Sequence Homology, Nucleic Acid Valine - chemistry
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Beschreibung
Zusammenfassung:	Summary The mouse CD1 system is formed by two closely related genes named Cd1d1 and Cd1d2. Cd1d1 encodes a molecule that presents antigens to NKT cells. The function of the Cd1d2 gene has not been elucidated. Here we described a method to analyse variations in mouse Cd1 genes. We found a new allele for Cd1d2 characterized by a point mutation, resulting in a replacement of alanine at position 176 by a valine.
ISSN:	0960-7420 1365-2370
DOI:	10.1111/j.1365-2370.2004.00431.x