Muscle strength following direct injection of doxorubicin into rabbit sternocleidomastoid muscle in situ
Direct intramuscular injection of doxorubicin results in permanent myofiber loss. A previous phase I trial demonstrated that such injections could successfully treat blepharospasm and hemifacial spasm. Our previous in vitro study demonstrated that doxorubicin resulted in a dose‐dependent reduction i...
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Veröffentlicht in: | Muscle & nerve 2002-05, Vol.25 (5), p.735-741 |
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Sprache: | eng |
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Zusammenfassung: | Direct intramuscular injection of doxorubicin results in permanent myofiber loss. A previous phase I trial demonstrated that such injections could successfully treat blepharospasm and hemifacial spasm. Our previous in vitro study demonstrated that doxorubicin resulted in a dose‐dependent reduction in isometric force generation in sternocleidomastoid muscle in rabbits. This present study examined alterations in force generation in these treated muscles in situ, i.e., with the blood and nerve supply intact. Two months after a single doxorubicin injection, functional changes in peak twitch, tetanic force generation, and fatigue rate were assessed in control and doxorubicin‐treated sternocleidomastoid muscles in rabbits. Peak force measurements were reduced in the treated muscles. These reductions in muscle strength were significantly greater at tetanic peak amplitudes. Fatigue rate was not altered by doxorubicin treatment of the sternocleidomastoid muscles. These findings support the potential clinical use of doxorubicin chemomyectomy for the treatment of patients with cervical dystonia. © 2002 Wiley Periodicals, Inc. Muscle Nerve 25: 000–000, 2002 |
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ISSN: | 0148-639X 1097-4598 |
DOI: | 10.1002/mus.10082 |