Early postoperative indicators of late outcome in acromegalic patients

Summary objective According to current criteria, normalised serum IGF‐1 and glucose‐suppressed GH 4 ng/ml attained IGF‐1 normalisation. Both univariate and multivariate analyses indicated that early glucose‐suppressed GH was a significant factor for predicting late normalised IGF‐1; the cut‐off va...

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Veröffentlicht in:	Clinical endocrinology (Oxford) 2004-03, Vol.60 (3), p.366-374
Hauptverfasser:	Takahashi, Jun A., Shimatsu, Akira, Nakao, Kazuwa, Hashimoto, Nobuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acromegaly - etiology Acromegaly - surgery Adenoma - blood Adenoma - complications Adenoma - surgery Adolescent Adult Aged Biological and medical sciences Depression, Chemical Endocrinopathies Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Glucose Growth Hormone - blood Humans Hypothalamus. Hypophysis. Epiphysis (diseases) Insulin-Like Growth Factor I - analysis Logistic Models Male Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Pituitary Neoplasms - blood Pituitary Neoplasms - complications Pituitary Neoplasms - surgery Postoperative Period Retrospective Studies Treatment Outcome Vertebrates: endocrinology
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Zusammenfassung:	Summary objective According to current criteria, normalised serum IGF‐1 and glucose‐suppressed GH 4 ng/ml attained IGF‐1 normalisation. Both univariate and multivariate analyses indicated that early glucose‐suppressed GH was a significant factor for predicting late normalised IGF‐1; the cut‐off value was 1·5 ng/ml (sensitivity: 0·97; specificity: 0·75; odds ratio: 90). conclusion The attainment of both normalised IGF‐1 and glucose‐suppressed GH
ISSN:	0300-0664 1365-2265
DOI:	10.1046/j.1365-2265.2003.01900.x