Electrospray ionization mass spectrometric studies of phosphorus oxychloride directed synthesis of homo-oligopeptide ester libraries

With the assistance of phosphorus oxychloride, α‐amino acids were assembled into homo‐peptides, which were analyzed by electrospray ionization mass spectrometry (ESI‐MS) and multistage electrospray ionization mass spectrometry (ESI‐MS/MS). On quenching with water or various alcohols, the reaction mixtures yielded the corresponding peptides or peptide esters, respectively. This paper reports a simple method to synthesize the homo‐oligo‐peptide‐ester conjugated library by phosphorus oxychloride activation. Copyright © 2002 John Wiley & Sons, Ltd.