Cytotoxic and Anti-HIV Principles from the Rhizomes of Begonia nantoensis
Three new compounds: begonanline (1), nantoamide (2) and methyl (S)-glycerate (3) as well as forty-four known compounds have been isolated and characterized from the rhizomes of Begonia nantoensis. The structures of these compounds were determined by spectral analyses and/or X-ray crystallography. A...
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Veröffentlicht in: | Chemical & pharmaceutical bulletin 2004, Vol.52(3), pp.345-349 |
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Zusammenfassung: | Three new compounds: begonanline (1), nantoamide (2) and methyl (S)-glycerate (3) as well as forty-four known compounds have been isolated and characterized from the rhizomes of Begonia nantoensis. The structures of these compounds were determined by spectral analyses and/or X-ray crystallography. Among them, cucurbitacin B (4), dihydrocucurbitacin B (5), cucurbitacin E (6), dihydrocucurbitacin E (7), cucurbitacin I (8), and (−)-auranamide (9) showed cytotoxicity against four human cancer cell lines. 3β,22α-Dihydroxyolean-12-en-29-oic acid (10), indole-3-carboxylic acid (11), 5,7-dihydroxychromone (12), and (−)-catechin (13) demonstrated significant activity against HIV replication in H9 lymphocyte cells. |
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ISSN: | 0009-2363 1347-5223 |
DOI: | 10.1248/cpb.52.345 |