Role of xanthine oxidase in conduit artery endothelial dysfunction in cigarette smokers

Xanthine oxidase contributes to oxidant stress and has been proposed as a risk factor for endothelial dysfunction. We studied the role of xanthine oxidase in conduit artery endothelial dysfunction in 12 smokers and 12 controls. Conduit artery vasodilation was impaired in smokers (4.3%) compared with...

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Veröffentlicht in:	The American journal of cardiology 2004-03, Vol.93 (5), p.664-668
Hauptverfasser:	Guthikonda, Sashi, Woods, Kenneth, Sinkey, Christine A., Haynes, William G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Allopurinol - pharmacology Biological and medical sciences Blood Flow Velocity - drug effects Blood Flow Velocity - physiology Brachial Artery - diagnostic imaging Brachial Artery - drug effects Brachial Artery - physiopathology Cardiology Cardiology. Vascular system Cardiovascular disease Coronary vessels Cross-Over Studies Endothelium, Vascular - diagnostic imaging Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Enzyme Inhibitors - pharmacology Female Humans Male Medical sciences Middle Aged Single-Blind Method Smoking Smoking - physiopathology Ultrasonography Vasodilation - drug effects Vasodilation - physiology Xanthine Oxidase - antagonists & inhibitors Xanthine Oxidase - physiology
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Zusammenfassung:	Xanthine oxidase contributes to oxidant stress and has been proposed as a risk factor for endothelial dysfunction. We studied the role of xanthine oxidase in conduit artery endothelial dysfunction in 12 smokers and 12 controls. Conduit artery vasodilation was impaired in smokers (4.3%) compared with controls (7.9%) (p = 0.006) and improved with xanthine oxidase inhibition in smokers (9.2%, p
ISSN:	0002-9149 1879-1913
DOI:	10.1016/j.amjcard.2003.11.046