Transition state isosteres of the γ-glutamyl peptide bond hydrolysis: synthesis and characterization of the ψ[CH2NH] pseudopeptide analogue of glutathione

The fully deprotected glutathione analogue containing the aminomethylene unit as transition state isostere of the γ‐Glu‐Cys peptide bond was synthesized for the first time and characterized in both the reduced and oxidized forms. Copyright © 2003 European Peptide Society and John Wiley & Sons, L...

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Veröffentlicht in:	Journal of peptide science 2004-02, Vol.10 (2), p.109-114
Hauptverfasser:	Cacciatore, Ivana, Stefano, Antonio Di, Luisi, Grazia, Pinnen, Francesco, Sozio, Piera
Format:	Artikel
Sprache:	eng
Schlagworte:	glutathione Glutathione - analogs & derivatives Glutathione - chemical synthesis Glutathione - chemistry Hydrolysis Magnetic Resonance Spectroscopy Molecular Structure Peptides - chemical synthesis Peptides - chemistry reduced peptides transition state analogue γ-glutamyl peptide bond
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Beschreibung
Zusammenfassung:	The fully deprotected glutathione analogue containing the aminomethylene unit as transition state isostere of the γ‐Glu‐Cys peptide bond was synthesized for the first time and characterized in both the reduced and oxidized forms. Copyright © 2003 European Peptide Society and John Wiley & Sons, Ltd.
ISSN:	1075-2617 1099-1387
DOI:	10.1002/psc.501