5-Substituted isophthalamides as insulin receptor sensitizers

A novel series of 5-substituted isophthalamides and their structure–activity relationship as insulin receptor sensitizers is discussed. A novel series of 5-substituted isophthalamides and their structure–activity relationship as insulin receptor sensitizers is discussed.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-06, Vol.18 (12), p.3492-3494
Hauptverfasser:	Robinson, Louise, Bajjalieh, Sonia, Cairns, Nicholas, Lum, Robert T., Macsata, Robert W., Manchem, Vara Prasad, Park, Sophia J., Rao, Sandhya, Schow, Steven R., Shi, Songyuan, Spevak, Wayne R.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipocytes - drug effects Adipocytes - metabolism Amides - chemical synthesis Amides - chemistry Amides - pharmacology Animals Biological and medical sciences Diabetes Drug Evaluation, Preclinical General and cellular metabolism. Vitamins Glucose - pharmacokinetics Insulin - pharmacology Insulin receptor Insulin resistance Medical sciences Mice Molecular Structure Pharmacology. Drug treatments Receptor, Insulin - drug effects SAR Stereoisomerism Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	A novel series of 5-substituted isophthalamides and their structure–activity relationship as insulin receptor sensitizers is discussed. A novel series of 5-substituted isophthalamides and their structure–activity relationship as insulin receptor sensitizers is discussed.
ISSN:	0960-894X 0968-0896 1464-3405 1464-3391
DOI:	10.1016/j.bmcl.2008.05.031