Cytochrome P-450 Inhibition Attenuates Hypertension Induced by Reductions in Uterine Perfusion Pressure in Pregnant Rats

ABSTRACT—The present study tested the hypothesis that cytochrome P-450 (CYP) metabolites of arachidonic acid (AA) are involved in mediating hypertension and renal vasoconstriction during chronic reductions in uterine perfusion pressure (RUPP) in pregnant rats. 1-aminobenzotriazole (ABT), a CYP enzym...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2004-03, Vol.43 (3), p.623-628
Hauptverfasser:	Llinás, Maria T, Alexander, Barbara T, Capparelli, Maria F, Carroll, Mairead A, Granger, Joey P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acids - metabolism Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Cytochrome P-450 CYP4A - metabolism Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors - pharmacology Experimental diseases Female Hemodynamics - drug effects Hypertension - etiology Kidney - physiopathology Kidney Cortex - metabolism Medical sciences Pre-Eclampsia - enzymology Pre-Eclampsia - etiology Pre-Eclampsia - physiopathology Pregnancy Rats Rats, Sprague-Dawley Triazoles - pharmacology Uterus - blood supply
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	ABSTRACT—The present study tested the hypothesis that cytochrome P-450 (CYP) metabolites of arachidonic acid (AA) are involved in mediating hypertension and renal vasoconstriction during chronic reductions in uterine perfusion pressure (RUPP) in pregnant rats. 1-aminobenzotriazole (ABT), a CYP enzyme inhibitor (25 mg/kg per day), or vehicle (saline 0.9%) was administered for 7 days to normal pregnant (NP) rats and to pregnant rats with chronic RUPP. RUPP rats infused with vehicle showed significantly (P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/01.HYP.0000117721.83371.9f