The Exceptional Glutathione Peroxidase-Like Activity of Di(3-hydroxypropyl) Selenide and the Unexpected Role of a Novel Spirodioxaselenanonane Intermediate in the Catalytic Cycle

The Exceptional Glutathione Peroxidase-Like Activity of Di(3-hydroxypropyl) Selenide and the Unexpected Role of a Novel Spirodioxaselenanonane Intermediate in the Catalytic Cycle

A new mechanism for reducing oxidative stress: Di(3‐hydroxypropyl) selenide has exceptionally high glutathione peroxidase‐like catalytic activity in the reduction of tert‐butyl hydroperoxide with benzyl thiol. The catalytic cycle proceeds via a novel spirodioxaselenanonane, which was isolated and ch...

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Veröffentlicht in:Angewandte Chemie International Edition 2004-02, Vol.43 (10), p.1268-1270
Hauptverfasser: Back, Thomas G., Moussa, Ziad, Parvez, Masood
Format: Artikel
Sprache:eng
Schlagworte:
oxidative stress
peroxidases
selenium
spiro compounds
thiols
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Zusammenfassung:A new mechanism for reducing oxidative stress: Di(3‐hydroxypropyl) selenide has exceptionally high glutathione peroxidase‐like catalytic activity in the reduction of tert‐butyl hydroperoxide with benzyl thiol. The catalytic cycle proceeds via a novel spirodioxaselenanonane, which was isolated and characterized spectroscopically, as well as by X‐ray crystallography.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200353128