Twenty-Four Hour 17-Hydroxyprogesterone Response to Adrenocorticotropine in Adrenal Incidentalomas: Augmented Response after Adrenalectomy in Two Patients

The current study aimed to investigate the midterm (24 hour) response of 17-hydroxyprogesterone (17-OHP) and dehydroepiandrosterone sulphate (DHEA-S) to synthetic high-dose adrenocorticotropin (ACTH) in adrenal incidentalomas (AI). Seventeen patients with AI and 40 age- and sex-matched controls rece...

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Veröffentlicht in:Endocrine Journal 2002, Vol.49(1), pp.35-40
Hauptverfasser: KAMEL, NURI, ERDOGAN, MURAT FAIK, TONYUKUK, VEDIA, ILGIN, SEN DAGCI, ERDOGAN, GÜRBÜZ
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Sprache:eng
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Zusammenfassung:The current study aimed to investigate the midterm (24 hour) response of 17-hydroxyprogesterone (17-OHP) and dehydroepiandrosterone sulphate (DHEA-S) to synthetic high-dose adrenocorticotropin (ACTH) in adrenal incidentalomas (AI). Seventeen patients with AI and 40 age- and sex-matched controls received synthetic ACTH (tetracosactide, 1000 μg, IM). Plasma, 17-OHP and DHEA-S were collected in basal conditions and after 1, 4, 6, 8 and 24 hours. (HPA) axis was also evaluated using circadian serum cortisol, urinary free cortisol and over-night 2 mg dexamethasone suppression. Basal plasma 17-OHP levels did not differ among the groups. However, the increment in plasma 17-OHP in patients both in terms of peak [13.76±2.52, 4.77±0.30 ng/ml, mean±S.E.M, p
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.49.35