Improved Glucose Excursions Using an Implantable Real-Time Continuous Glucose Sensor in Adults With Type 1 Diabetes

Improved Glucose Excursions Using an Implantable Real-Time Continuous Glucose Sensor in Adults With Type 1 Diabetes Satish K. Garg , MD 1 , Sherwyn Schwartz , MD 2 and Steven V. Edelman , MD 3 1 Department of Medicine and Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 2 Diabetes & Glandular Disease Research Associates, San Antonio, Texas 3 Department of Medicine, University of California, San Diego, California Address correspondence and reprint requests to Satish K. Garg, MD, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Ave., Campus Box B-140, Denver, CO 80262. E-mail: satish.garg{at}uchsc.edu Abstract OBJECTIVE —The capability of emerging glucose sensor technology to continuously monitor glucose levels may provide ways to achieve glycemic targets while reducing hypoglycemia. RESEARCH DESIGN AND METHODS —A first-generation, long-term continuous glucose sensor (DexCom, San Diego, CA) was implanted subcutaneously in 15 patients with type 1 diabetes. Safety, efficacy, and potential benefits were evaluated during a blinded control period and in a study period during which patients had real-time access to the glucose data. RESULTS —The bias differences between self-monitored blood glucose (SMBG) and sensor data were