Antioxidant activity and metabolite profile of quercetin in vitamin-E-depleted rats
Dietary antioxidants interact in a dynamic fashion, including recycling and sparing one another, to decrease oxidative stress. Limited information is available regarding the interrelationships in vivo between quercetin and vitamin E. We investigated the antioxidant activity and metabolism of quercet...
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| Veröffentlicht in: | The Journal of nutritional biochemistry 2008-07, Vol.19 (7), p.467-474 |
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| creator | Ameho, Clement K. Chen, C.-Y. Oliver Smith, Donald Sánchez-Moreno, Concepción Milbury, Paul E. Blumberg, Jeffrey B. |
| description | Dietary antioxidants interact in a dynamic fashion, including recycling and sparing one another, to decrease oxidative stress. Limited information is available regarding the interrelationships in vivo between quercetin and vitamin E. We investigated the antioxidant activity and metabolism of quercetin (Q) in 65 F-344 rats (
n=13 per group) randomly assigned to the following vitamin E (VE)-replete and -deficient diets: (a) VE replete (30 mg α-tocopherol acetate/kg diet) control ad libitum (C-AL), (b) VE replete pair fed (C-PF), (c) VE replete+5.0 g Q/kg diet (R-VE+5Q), (d) VE deplete ( |
| doi_str_mv | 10.1016/j.jnutbio.2007.06.004 |
| format | Article |
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n=13 per group) randomly assigned to the following vitamin E (VE)-replete and -deficient diets: (a) VE replete (30 mg α-tocopherol acetate/kg diet) control ad libitum (C-AL), (b) VE replete pair fed (C-PF), (c) VE replete+5.0 g Q/kg diet (R-VE+5Q), (d) VE deplete (<1 mg/kg total tocopherols)+5.0 g Q/kg diet (D-VE+5Q) and (e) D-VE. After 12 weeks, blood and tissue were collected for measurement of plasma vitamin E, quercetin and its metabolites, serum pyruvate kinase (PK), plasma protein carbonyls, malondialdehyde (MDA) and oxygen radical absorbance capacity. D-VE diets decreased serum α-tocopherol and increased PK activity in a time-dependent manner. The D-VE diet increased plasma protein carbonyls but did not affect MDA. Dietary quercetin supplementation increased quercetin and its metabolites in plasma and liver but did not affect D-VE-induced changes in plasma α-tocopherol, PK or protein carbonyls. Plasma isorhamnetin and its disposition in muscle were enhanced by the D-VE diet, as compared to the R-VE diet. Conversely, tamarixetin disposition in muscle was decreased by the D-VE diet. Thus, quercetin did not slow vitamin E decline in vivo; neither did it provide antioxidant activity in vitamin-E-depleted rats. However, vitamin E status appears to enhance the distribution of isorhamnetin into the circulation and its disposition in muscle.</description><identifier>ISSN: 0955-2863</identifier><identifier>EISSN: 1873-4847</identifier><identifier>DOI: 10.1016/j.jnutbio.2007.06.004</identifier><identifier>PMID: 17904346</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>alpha-tocopherol ; alpha-Tocopherol - blood ; animal models ; Animals ; antioxidant activity ; Antioxidants ; Antioxidants - metabolism ; Biological and medical sciences ; blood serum ; blood serum protein carbonyls ; carbonyl compounds ; chemical constituents of plants ; Feeding. Feeding behavior ; free radical scavengers ; free radicals ; Fundamental and applied biological sciences. Psychology ; gamma-tocopherol ; intestinal absorption ; isorhamnetin ; liver ; Male ; malondialdehyde ; Metabolism ; nutrient availability ; nutrient-nutrient interactions ; nutritional status ; Oxidative Stress ; oxygen ; plant-based foods ; pyruvate kinase ; Pyruvate Kinase - blood ; Quercetin ; Quercetin - metabolism ; Rats ; reactive oxygen species ; secondary metabolites ; skeletal muscle ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; vitamin deficiencies ; Vitamin E Deficiency - blood ; Vitamin E Deficiency - metabolism ; vitamin metabolism ; vitamin supplements ; α-Tocopherol</subject><ispartof>The Journal of nutritional biochemistry, 2008-07, Vol.19 (7), p.467-474</ispartof><rights>2008 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-4c4bbe2b9cc229cf130fb5c23ba17740f01965518583af1669621f90403e751a3</citedby><cites>FETCH-LOGICAL-c483t-4c4bbe2b9cc229cf130fb5c23ba17740f01965518583af1669621f90403e751a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S095528630700160X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20465931$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17904346$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ameho, Clement K.</creatorcontrib><creatorcontrib>Chen, C.-Y. Oliver</creatorcontrib><creatorcontrib>Smith, Donald</creatorcontrib><creatorcontrib>Sánchez-Moreno, Concepción</creatorcontrib><creatorcontrib>Milbury, Paul E.</creatorcontrib><creatorcontrib>Blumberg, Jeffrey B.</creatorcontrib><title>Antioxidant activity and metabolite profile of quercetin in vitamin-E-depleted rats</title><title>The Journal of nutritional biochemistry</title><addtitle>J Nutr Biochem</addtitle><description>Dietary antioxidants interact in a dynamic fashion, including recycling and sparing one another, to decrease oxidative stress. Limited information is available regarding the interrelationships in vivo between quercetin and vitamin E. We investigated the antioxidant activity and metabolism of quercetin (Q) in 65 F-344 rats (
n=13 per group) randomly assigned to the following vitamin E (VE)-replete and -deficient diets: (a) VE replete (30 mg α-tocopherol acetate/kg diet) control ad libitum (C-AL), (b) VE replete pair fed (C-PF), (c) VE replete+5.0 g Q/kg diet (R-VE+5Q), (d) VE deplete (<1 mg/kg total tocopherols)+5.0 g Q/kg diet (D-VE+5Q) and (e) D-VE. After 12 weeks, blood and tissue were collected for measurement of plasma vitamin E, quercetin and its metabolites, serum pyruvate kinase (PK), plasma protein carbonyls, malondialdehyde (MDA) and oxygen radical absorbance capacity. D-VE diets decreased serum α-tocopherol and increased PK activity in a time-dependent manner. The D-VE diet increased plasma protein carbonyls but did not affect MDA. Dietary quercetin supplementation increased quercetin and its metabolites in plasma and liver but did not affect D-VE-induced changes in plasma α-tocopherol, PK or protein carbonyls. Plasma isorhamnetin and its disposition in muscle were enhanced by the D-VE diet, as compared to the R-VE diet. Conversely, tamarixetin disposition in muscle was decreased by the D-VE diet. Thus, quercetin did not slow vitamin E decline in vivo; neither did it provide antioxidant activity in vitamin-E-depleted rats. However, vitamin E status appears to enhance the distribution of isorhamnetin into the circulation and its disposition in muscle.</description><subject>alpha-tocopherol</subject><subject>alpha-Tocopherol - blood</subject><subject>animal models</subject><subject>Animals</subject><subject>antioxidant activity</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Biological and medical sciences</subject><subject>blood serum</subject><subject>blood serum protein carbonyls</subject><subject>carbonyl compounds</subject><subject>chemical constituents of plants</subject><subject>Feeding. Feeding behavior</subject><subject>free radical scavengers</subject><subject>free radicals</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gamma-tocopherol</subject><subject>intestinal absorption</subject><subject>isorhamnetin</subject><subject>liver</subject><subject>Male</subject><subject>malondialdehyde</subject><subject>Metabolism</subject><subject>nutrient availability</subject><subject>nutrient-nutrient interactions</subject><subject>nutritional status</subject><subject>Oxidative Stress</subject><subject>oxygen</subject><subject>plant-based foods</subject><subject>pyruvate kinase</subject><subject>Pyruvate Kinase - blood</subject><subject>Quercetin</subject><subject>Quercetin - metabolism</subject><subject>Rats</subject><subject>reactive oxygen species</subject><subject>secondary metabolites</subject><subject>skeletal muscle</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>vitamin deficiencies</subject><subject>Vitamin E Deficiency - blood</subject><subject>Vitamin E Deficiency - metabolism</subject><subject>vitamin metabolism</subject><subject>vitamin supplements</subject><subject>α-Tocopherol</subject><issn>0955-2863</issn><issn>1873-4847</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M1u1DAUBWALgei08AhANrBLuP5PVqiqSkGqxKJ0bTnONfIocQbbU7Vvj6uJYIlkyZvv2uceQt5R6ChQ9Xnf7eOxjGHtGIDuQHUA4gXZ0V7zVvRCvyQ7GKRsWa_4GTnPeQ8ATEj1mpxRPYDgQu3I3WUsYX0Mk42lsa6Eh1CeGhunZsFix3UOBZtDWn2YsVl98_uIyWEJsamnWruE2F63Ex5mLDg1yZb8hrzyds74drsvyP3X659X39rbHzffry5vWyd6XlrhxDgiGwfnGBucpxz8KB3jo6VaC_BAByUl7WXPradKDYpRX4MDRy2p5Rfk0-ndmq_mysUsITucZxtxPWajqdI9ZapCeYIurTkn9OaQwmLTk6Fgnts0e7O1aZ7bNKBMbbPOvd8-OI4LTv-mtvoq-LgBm52dfbLRhfzXMRBKDpxW9-HkvF2N_ZWqub9jUDeGAbQGXsWXk8Ba2EPAZLILGB1OIaErZlrDf8L-AXRKnrQ</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Ameho, Clement K.</creator><creator>Chen, C.-Y. 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Oliver ; Smith, Donald ; Sánchez-Moreno, Concepción ; Milbury, Paul E. ; Blumberg, Jeffrey B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-4c4bbe2b9cc229cf130fb5c23ba17740f01965518583af1669621f90403e751a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>alpha-tocopherol</topic><topic>alpha-Tocopherol - blood</topic><topic>animal models</topic><topic>Animals</topic><topic>antioxidant activity</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Biological and medical sciences</topic><topic>blood serum</topic><topic>blood serum protein carbonyls</topic><topic>carbonyl compounds</topic><topic>chemical constituents of plants</topic><topic>Feeding. Feeding behavior</topic><topic>free radical scavengers</topic><topic>free radicals</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gamma-tocopherol</topic><topic>intestinal absorption</topic><topic>isorhamnetin</topic><topic>liver</topic><topic>Male</topic><topic>malondialdehyde</topic><topic>Metabolism</topic><topic>nutrient availability</topic><topic>nutrient-nutrient interactions</topic><topic>nutritional status</topic><topic>Oxidative Stress</topic><topic>oxygen</topic><topic>plant-based foods</topic><topic>pyruvate kinase</topic><topic>Pyruvate Kinase - blood</topic><topic>Quercetin</topic><topic>Quercetin - metabolism</topic><topic>Rats</topic><topic>reactive oxygen species</topic><topic>secondary metabolites</topic><topic>skeletal muscle</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>vitamin deficiencies</topic><topic>Vitamin E Deficiency - blood</topic><topic>Vitamin E Deficiency - metabolism</topic><topic>vitamin metabolism</topic><topic>vitamin supplements</topic><topic>α-Tocopherol</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ameho, Clement K.</creatorcontrib><creatorcontrib>Chen, C.-Y. Oliver</creatorcontrib><creatorcontrib>Smith, Donald</creatorcontrib><creatorcontrib>Sánchez-Moreno, Concepción</creatorcontrib><creatorcontrib>Milbury, Paul E.</creatorcontrib><creatorcontrib>Blumberg, Jeffrey B.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutritional biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ameho, Clement K.</au><au>Chen, C.-Y. 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n=13 per group) randomly assigned to the following vitamin E (VE)-replete and -deficient diets: (a) VE replete (30 mg α-tocopherol acetate/kg diet) control ad libitum (C-AL), (b) VE replete pair fed (C-PF), (c) VE replete+5.0 g Q/kg diet (R-VE+5Q), (d) VE deplete (<1 mg/kg total tocopherols)+5.0 g Q/kg diet (D-VE+5Q) and (e) D-VE. After 12 weeks, blood and tissue were collected for measurement of plasma vitamin E, quercetin and its metabolites, serum pyruvate kinase (PK), plasma protein carbonyls, malondialdehyde (MDA) and oxygen radical absorbance capacity. D-VE diets decreased serum α-tocopherol and increased PK activity in a time-dependent manner. The D-VE diet increased plasma protein carbonyls but did not affect MDA. Dietary quercetin supplementation increased quercetin and its metabolites in plasma and liver but did not affect D-VE-induced changes in plasma α-tocopherol, PK or protein carbonyls. Plasma isorhamnetin and its disposition in muscle were enhanced by the D-VE diet, as compared to the R-VE diet. Conversely, tamarixetin disposition in muscle was decreased by the D-VE diet. Thus, quercetin did not slow vitamin E decline in vivo; neither did it provide antioxidant activity in vitamin-E-depleted rats. However, vitamin E status appears to enhance the distribution of isorhamnetin into the circulation and its disposition in muscle.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17904346</pmid><doi>10.1016/j.jnutbio.2007.06.004</doi><tpages>8</tpages></addata></record> |
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| subjects | alpha-tocopherol alpha-Tocopherol - blood animal models Animals antioxidant activity Antioxidants Antioxidants - metabolism Biological and medical sciences blood serum blood serum protein carbonyls carbonyl compounds chemical constituents of plants Feeding. Feeding behavior free radical scavengers free radicals Fundamental and applied biological sciences. Psychology gamma-tocopherol intestinal absorption isorhamnetin liver Male malondialdehyde Metabolism nutrient availability nutrient-nutrient interactions nutritional status Oxidative Stress oxygen plant-based foods pyruvate kinase Pyruvate Kinase - blood Quercetin Quercetin - metabolism Rats reactive oxygen species secondary metabolites skeletal muscle Vertebrates: anatomy and physiology, studies on body, several organs or systems vitamin deficiencies Vitamin E Deficiency - blood Vitamin E Deficiency - metabolism vitamin metabolism vitamin supplements α-Tocopherol |
| title | Antioxidant activity and metabolite profile of quercetin in vitamin-E-depleted rats |
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