Antioxidant activity and metabolite profile of quercetin in vitamin-E-depleted rats

Dietary antioxidants interact in a dynamic fashion, including recycling and sparing one another, to decrease oxidative stress. Limited information is available regarding the interrelationships in vivo between quercetin and vitamin E. We investigated the antioxidant activity and metabolism of quercet...

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Veröffentlicht in:	The Journal of nutritional biochemistry 2008-07, Vol.19 (7), p.467-474
Hauptverfasser:	Ameho, Clement K., Chen, C.-Y. Oliver, Smith, Donald, Sánchez-Moreno, Concepción, Milbury, Paul E., Blumberg, Jeffrey B.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-tocopherol alpha-Tocopherol - blood animal models Animals antioxidant activity Antioxidants Antioxidants - metabolism Biological and medical sciences blood serum blood serum protein carbonyls carbonyl compounds chemical constituents of plants Feeding. Feeding behavior free radical scavengers free radicals Fundamental and applied biological sciences. Psychology gamma-tocopherol intestinal absorption isorhamnetin liver Male malondialdehyde Metabolism nutrient availability nutrient-nutrient interactions nutritional status Oxidative Stress oxygen plant-based foods pyruvate kinase Pyruvate Kinase - blood Quercetin Quercetin - metabolism Rats reactive oxygen species secondary metabolites skeletal muscle Vertebrates: anatomy and physiology, studies on body, several organs or systems vitamin deficiencies Vitamin E Deficiency - blood Vitamin E Deficiency - metabolism vitamin metabolism vitamin supplements α-Tocopherol
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Zusammenfassung:	Dietary antioxidants interact in a dynamic fashion, including recycling and sparing one another, to decrease oxidative stress. Limited information is available regarding the interrelationships in vivo between quercetin and vitamin E. We investigated the antioxidant activity and metabolism of quercetin (Q) in 65 F-344 rats ( n=13 per group) randomly assigned to the following vitamin E (VE)-replete and -deficient diets: (a) VE replete (30 mg α-tocopherol acetate/kg diet) control ad libitum (C-AL), (b) VE replete pair fed (C-PF), (c) VE replete+5.0 g Q/kg diet (R-VE+5Q), (d) VE deplete (
ISSN:	0955-2863 1873-4847
DOI:	10.1016/j.jnutbio.2007.06.004