Interstitial radiosurgery in the treatment of gelastic epilepsy due to hypothalamic hamartomas

The authors evaluated a new stereotactic radiosurgical approach in seven patients with gelastic epilepsy due to hypothalamic hamartomas. Stereotactic implantation of 125I-seeds into the hamartoma was feasible in six patients. At follow-up at least 1 year after interstitial radiotherapy, two patients...

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Veröffentlicht in:	Neurology 2004-02, Vol.62 (4), p.644-647
Hauptverfasser:	SCHULZE-BONHAGE, A, HOMBERG, V, TRIPPEL, M, KEIMER, R, ELGER, C. E, WARNKE, P. C, OSTERTAG, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological and medical sciences Brachytherapy - methods Child Drug Implants Drug Resistance Epilepsies, Partial - etiology Epilepsies, Partial - radiotherapy Epilepsies, Partial - surgery Female Follow-Up Studies Hamartoma - complications Hamartoma - radiotherapy Hamartoma - surgery Humans Hypothalamic Diseases - complications Hypothalamic Diseases - radiotherapy Hypothalamic Diseases - surgery Iodine Radioisotopes - administration & dosage Iodine Radioisotopes - therapeutic use Male Medical sciences Neurology Radiosurgery - methods Treatment Outcome
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Zusammenfassung:	The authors evaluated a new stereotactic radiosurgical approach in seven patients with gelastic epilepsy due to hypothalamic hamartomas. Stereotactic implantation of 125I-seeds into the hamartoma was feasible in six patients. At follow-up at least 1 year after interstitial radiotherapy, two patients had become seizure-free within 2 months, and two others had only persisting auras. There were no major perioperative or postoperative side effects.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/01.WNL.0000110194.77056.65