Silicon-Based Building Blocks for One-Step ¹⁸F-Radiolabeling of Peptides for PET Imaging

Radio‐controlled landing of F: The facile 18F labeling of biomolecules has been achieved under mild conditions by using a unique silicon‐based one‐step approach (see scheme). A di‐tert‐butylsilyl derivative with an aryl linker was attached to a tetrapeptide. The assembly shows a hydrolytic stability...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2008, Vol.47 (26), p.4922-4925
Hauptverfasser:	Mu, Linjing, Höhne, Aileen, Schubiger, P. August, Ametamey, Simon M, Graham, Keith, Cyr, John E, Dinkelborg, Ludger, Stellfeld, Timo, Srinivasan, Ananth, Voigtmann, Ulrike, Klar, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	fluorine Fluorine Radioisotopes - chemistry Molecular Structure peptides Peptides - analysis Peptides - chemistry PET imaging Positron-Emission Tomography - methods radiolabeling silicon Silicon - chemistry Time Factors
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Beschreibung
Zusammenfassung:	Radio‐controlled landing of F: The facile 18F labeling of biomolecules has been achieved under mild conditions by using a unique silicon‐based one‐step approach (see scheme). A di‐tert‐butylsilyl derivative with an aryl linker was attached to a tetrapeptide. The assembly shows a hydrolytic stability that appears to be within the range required for in vivo positron emission tomography (PET) imaging applications.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200705854