CHARACTERIZATION OF KLEBSIELLA PNEUMONIAE AND ESCHERICHIA COLI STRAINS THAT PRODUCE CTX-M-2-TYPE BROAD SPECTRUM BETA-LACTAMASE ISOLATED FROM A CHILD WITH LEUKEMIA

An 8-year-old girl with acute leukemia had bacteremia caused by Klebsiella pneumoniae producing CTX-M-2-type broad spectrum beta-lactamase. K. pneumoniae and Escherichia coli strains producing the same enzyme and harboring identical conjugative plasmids were recovered from stoor culture. Patients wi...

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Veröffentlicht in:	The Pediatric infectious disease journal 2002-03, Vol.21 (3), p.260-262
Hauptverfasser:	Ohkawa, Toshiya, Yoshinaga, Masao, Ikarimoto, Naoaki, Miyanohara, Hiroaki, Miyata, Koichiro, Doi, Yohei, Shibata, Naohiro, Arakawa, Yoshichika
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology beta-Lactamases - biosynthesis beta-Lactamases - genetics beta-Lactamases - metabolism Biological and medical sciences Child, Preschool Drug Resistance, Multiple, Bacterial Escherichia coli - classification Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli - isolation & purification Female Gene Expression Regulation, Bacterial Humans Infectious diseases Klebsiella pneumoniae - classification Klebsiella pneumoniae - enzymology Klebsiella pneumoniae - genetics Klebsiella pneumoniae - isolation & purification Medical sciences Microbial Sensitivity Tests Precursor Cell Lymphoblastic Leukemia-Lymphoma - microbiology Substrate Specificity
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Zusammenfassung:	An 8-year-old girl with acute leukemia had bacteremia caused by Klebsiella pneumoniae producing CTX-M-2-type broad spectrum beta-lactamase. K. pneumoniae and Escherichia coli strains producing the same enzyme and harboring identical conjugative plasmids were recovered from stoor culture. Patients with frequent episodes of neutropenia and prophylactic administration of beta-lactams are at risk of harboring colonizing strains that produce broad spectrum beta-lactamases.
ISSN:	0891-3668 1532-0987
DOI:	10.1097/00006454-200203000-00022