Conflict and Kala-Azar: Determinants of Adverse Outcomes of Kala-Azar among Patients in Southern Sudan

We analyzed data obtained from 3365 patients with kala-azar (KA) or post-KA dermal leishmaniasis (PKDL) treated by Médecins Sans Frontières–Holland in south Sudan from October 1998–May 2002. Patients were malnourished (median body mass index [BMI], 15.5; median weight for height [WFH], 75.5%) and an...

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Veröffentlicht in:	Clinical infectious diseases 2004-03, Vol.38 (5), p.612-619
Hauptverfasser:	Collin, Simon, Davidson, Robert, Ritmeijer, Koert, Keus, Kees, Melaku, Yosef, Kipngetich, Sammy, Davies, Clive
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age Age Factors Animals Antimony Sodium Gluconate - therapeutic use Biological and medical sciences Body mass index Body Weight - drug effects Child Child, Preschool Dosage Dose-Response Relationship, Drug Epidemics Female Human protozoal diseases Humans Infectious diseases Leishmania Leishmaniasis Leishmaniasis, Visceral - drug therapy Leishmaniasis, Visceral - epidemiology Leishmaniasis, Visceral - metabolism Leshmaniasis Major Articles Male Malnutrition Medical sciences Metabolic diseases Mortality Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Parasitic diseases Protozoal diseases Recurrence Relapse Risk Factors Sudan - epidemiology Treatment Outcome Visceral leishmaniasis Vomiting Warfare
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Zusammenfassung:	We analyzed data obtained from 3365 patients with kala-azar (KA) or post-KA dermal leishmaniasis (PKDL) treated by Médecins Sans Frontières–Holland in south Sudan from October 1998–May 2002. Patients were malnourished (median body mass index [BMI], 15.5; median weight for height [WFH], 75.5%) and anemic (median hemoglobin (Hb) level, 8.5 g/dL). The proportion of patients with primary KA who were children 850 mg per day did not decrease the chances of survival. Risk factors for death among adults were age ⩾45 years (odds ratio [OR], 4.6), malnutrition (BMI,
ISSN:	1058-4838 1537-6591
DOI:	10.1086/381203