Concise, Stereoselective Syntheses of cis-Nemorensic Acid and 4-Hydroxy-cis-nemorensic Acid via Tandem Carbonyl Ylide Formation−Cycloaddition
1,3-Dipolar cycloaddition of propargyl bromide with the carbonyl ylide derived from 6-diazoheptane-2,5-dione is the key step in concise syntheses of cis-nemorensic acid and 4-hydroxy-cis-nemorensic acid.
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| Veröffentlicht in: | Organic letters 2002-05, Vol.4 (10), p.1809-1811 |
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| container_title | Organic letters |
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| creator | Hodgson, David M Avery, Thomas D Donohue, Andrew C |
| description | 1,3-Dipolar cycloaddition of propargyl bromide with the carbonyl ylide derived from 6-diazoheptane-2,5-dione is the key step in concise syntheses of cis-nemorensic acid and 4-hydroxy-cis-nemorensic acid. |
| doi_str_mv | 10.1021/ol025917c |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1523-7060 |
| ispartof | Organic letters, 2002-05, Vol.4 (10), p.1809-1811 |
| issn | 1523-7060 1523-7052 |
| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Antineoplastic Agents, Phytogenic - chemical synthesis Catalysis Crystallography, X-Ray Cyclization Furans - chemical synthesis Furans - pharmacology Models, Molecular Pargyline - analogs & derivatives Pargyline - chemical synthesis Pargyline - pharmacology Pyrrolizidine Alkaloids - chemical synthesis Pyrrolizidine Alkaloids - pharmacology Senecio - chemistry Stereoisomerism |
| title | Concise, Stereoselective Syntheses of cis-Nemorensic Acid and 4-Hydroxy-cis-nemorensic Acid via Tandem Carbonyl Ylide Formation−Cycloaddition |
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