Concise, Stereoselective Syntheses of cis-Nemorensic Acid and 4-Hydroxy-cis-nemorensic Acid via Tandem Carbonyl Ylide Formation−Cycloaddition

1,3-Dipolar cycloaddition of propargyl bromide with the carbonyl ylide derived from 6-diazoheptane-2,5-dione is the key step in concise syntheses of cis-nemorensic acid and 4-hydroxy-cis-nemorensic acid.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Organic letters 2002-05, Vol.4 (10), p.1809-1811
Hauptverfasser:	Hodgson, David M, Avery, Thomas D, Donohue, Andrew C
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemical synthesis Catalysis Crystallography, X-Ray Cyclization Furans - chemical synthesis Furans - pharmacology Models, Molecular Pargyline - analogs & derivatives Pargyline - chemical synthesis Pargyline - pharmacology Pyrrolizidine Alkaloids - chemical synthesis Pyrrolizidine Alkaloids - pharmacology Senecio - chemistry Stereoisomerism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	1,3-Dipolar cycloaddition of propargyl bromide with the carbonyl ylide derived from 6-diazoheptane-2,5-dione is the key step in concise syntheses of cis-nemorensic acid and 4-hydroxy-cis-nemorensic acid.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol025917c