Polymorphisms of TNF-alpha and LT-alpha genes in multiple myeloma

Abstract Allelic distribution of −308 G > A ( TNF 1/2) polymorphism of the TNF-alpha , and the +252 A > G promoter polymorphism of the LT-alpha gene, the 1267 A > G polymorphism of the HSP70-2 gene as well as the −429 T > C promoter polymorphism of the RAGE gene were tested in 94 MM case...

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Veröffentlicht in:	Leukemia research 2008-10, Vol.32 (10), p.1499-1504
Hauptverfasser:	Kádár, Katalin, Kovács, Margit, Karádi, István, Melegh, Béla, Pocsai, Zsuzsa, Mikala, Gábor, Tordai, Attila, Szilágyi, Ágnes, Ádány, Róza, Füst, George, Várkonyi, Judit
Format:	Artikel
Sprache:	eng
Schlagworte:	8.1 ancestral haplotype Aged Ancestral haplotype Female Gene Frequency Genotype Haplotypes Heat shock protein 70 Hematology, Oncology and Palliative Medicine Humans Lymphotoxin-alpha Lymphotoxin-alpha - genetics Male Middle Aged Multiple myeloma Multiple Myeloma - diagnosis Multiple Myeloma - genetics Polymorphism, Single Nucleotide RAGE SNP TNF-alpha Tumor Necrosis Factor-alpha - genetics
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Zusammenfassung:	Abstract Allelic distribution of −308 G > A ( TNF 1/2) polymorphism of the TNF-alpha , and the +252 A > G promoter polymorphism of the LT-alpha gene, the 1267 A > G polymorphism of the HSP70-2 gene as well as the −429 T > C promoter polymorphism of the RAGE gene were tested in 94 MM cases and 141 controls. Significantly less MM patients than controls carried the TNF2 allele ( p = 0.018) and the TNF2-LTA 252G haplotype ( p = 0.025). The difference was, however, restricted to the females, as well as the relatively young (
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2008.03.001