Gianotti-Crosti Syndrome in Two Adult Patients

Background: Gianotti-Crosti syndrome was first described in Italy by Gianotti in 1955. It is considered a benign, self-limited exanthem that occurs in younger children. Adult cases are rare. Objective: We report two cases of Gianotti-Crosti syndrome in a previously healthy 37-year old Asian and 21-y...

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Veröffentlicht in:Journal of cutaneous medicine and surgery 2008-05, Vol.12 (3), p.121-125
Hauptverfasser: Ting, Patricia T., Barankin, Benjamin, Dytoc, Marlene T.
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Sprache:eng
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Zusammenfassung:Background: Gianotti-Crosti syndrome was first described in Italy by Gianotti in 1955. It is considered a benign, self-limited exanthem that occurs in younger children. Adult cases are rare. Objective: We report two cases of Gianotti-Crosti syndrome in a previously healthy 37-year old Asian and 21-year old Caucasian female. Methods/Results: Histopathological analysis of 4-mm punch biopsies from the upper extremity of both patients revealed an interstitial dermatitis with mild to moderate perivascular lymphocytic infiltrate and occasional scattered eosinophils in the superficial and mid-dermis. Clinicopathological correlation was consistent with Gianotti-Crosti syndrome. Conclusion: Since both patients experienced significant pruritus, patient 1 was initially treated with a high potency topical corticosteroid followed by a two-week course of oral prednisone and patient 2 was treated with a potent topical corticosteroid. Both patients were asymptomatic at follow-up 3 to 4 weeks after their initial presentation.
ISSN:1203-4754
1615-7109
DOI:10.2310/7750.2007.00044