Synthesis of Eudistomin C and E: Improved Preparation of the Indole Unit

Synthesis of Eudistomin C and E: Improved Preparation of the Indole Unit

An improved synthesis of the indole unit, a key intermediate for eudistomin C, was established utilizing Makosza’s indole synthesis. A concise total synthesis of eudistomin E was achieved on the basis of the improved synthesis.

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Veröffentlicht in:Organic letters 2008-06, Vol.10 (12), p.2369-2372
Hauptverfasser: Yamagishi, Hiroaki, Matsumoto, Koji, Iwasaki, Kotaro, Miyazaki, Tohru, Yokoshima, Satoshi, Tokuyama, Hidetoshi, Fukuyama, Tohru
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Carbolines - chemical synthesis
Indoles - chemical synthesis
Indoles - chemistry
Molecular Structure
Urochordata - chemistry
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Zusammenfassung:An improved synthesis of the indole unit, a key intermediate for eudistomin C, was established utilizing Makosza’s indole synthesis. A concise total synthesis of eudistomin E was achieved on the basis of the improved synthesis.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol800527p