A Role for CD147 in Thymic Development
We have previously identified a mAb that binds to a molecule expressed preferentially on the surface of cycling thymocytes. In this study the molecule recognized by this mAb has been identified in the mouse as CD147 (basigin) by expression cloning. We show that CD147 expression correlates with cycli...
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| Veröffentlicht in: | The Journal of immunology (1950) 2002-05, Vol.168 (10), p.4946-4950 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 168 |
| creator | Renno, Toufic Wilson, Anne Dunkel, Caroline Coste, Isabelle Maisnier-Patin, Karine Benoit de Coignac, Amelie Aubry, Jean-Pierre Lees, Rosemary K Bonnefoy, Jean-Yves MacDonald, H. Robson Gauchat, Jean-Francois |
| description | We have previously identified a mAb that binds to a molecule expressed preferentially on the surface of cycling thymocytes. In this study the molecule recognized by this mAb has been identified in the mouse as CD147 (basigin) by expression cloning. We show that CD147 expression correlates with cycling of immature thymocytes even in the absence of TCRbeta selection and that ligation of this molecule on immature fetal thymocytes inhibits their further development into mature T cells. |
| doi_str_mv | 10.4049/jimmunol.168.10.4946 |
| format | Article |
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Robson ; Gauchat, Jean-Francois</creator><creatorcontrib>Renno, Toufic ; Wilson, Anne ; Dunkel, Caroline ; Coste, Isabelle ; Maisnier-Patin, Karine ; Benoit de Coignac, Amelie ; Aubry, Jean-Pierre ; Lees, Rosemary K ; Bonnefoy, Jean-Yves ; MacDonald, H. Robson ; Gauchat, Jean-Francois</creatorcontrib><description>We have previously identified a mAb that binds to a molecule expressed preferentially on the surface of cycling thymocytes. In this study the molecule recognized by this mAb has been identified in the mouse as CD147 (basigin) by expression cloning. We show that CD147 expression correlates with cycling of immature thymocytes even in the absence of TCRbeta selection and that ligation of this molecule on immature fetal thymocytes inhibits their further development into mature T cells.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.168.10.4946</identifier><identifier>PMID: 11994445</identifier><language>eng</language><publisher>United States: Am Assoc Immnol</publisher><subject>Amino Acid Sequence ; Animals ; Antibodies, Monoclonal - metabolism ; Antigens, CD ; Antigens, Neoplasm ; Antigens, Surface ; Avian Proteins ; Base Sequence ; Basigin ; Binding Sites, Antibody - genetics ; Blood Proteins ; Cell Cycle - genetics ; Cell Cycle - immunology ; Cell Differentiation - genetics ; Cell Differentiation - immunology ; Cell Line ; Cloning, Molecular ; Female ; Fetus ; Humans ; Membrane Glycoproteins - biosynthesis ; Membrane Glycoproteins - genetics ; Membrane Glycoproteins - immunology ; Membrane Glycoproteins - physiology ; Membrane Proteins - genetics ; Membrane Proteins - immunology ; Membrane Proteins - metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Sequence Data ; Organ Culture Techniques ; Receptors, Antigen, T-Cell, alpha-beta - biosynthesis ; Thymus Gland - cytology ; Thymus Gland - embryology ; Thymus Gland - immunology ; Thymus Gland - metabolism ; Tumor Cells, Cultured</subject><ispartof>The Journal of immunology (1950), 2002-05, Vol.168 (10), p.4946-4950</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-4b41ce62eda4c7f6a75d75c09ae552d383c615950b7afd362183b70c9a77bfce3</citedby><cites>FETCH-LOGICAL-c479t-4b41ce62eda4c7f6a75d75c09ae552d383c615950b7afd362183b70c9a77bfce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11994445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Renno, Toufic</creatorcontrib><creatorcontrib>Wilson, Anne</creatorcontrib><creatorcontrib>Dunkel, Caroline</creatorcontrib><creatorcontrib>Coste, Isabelle</creatorcontrib><creatorcontrib>Maisnier-Patin, Karine</creatorcontrib><creatorcontrib>Benoit de Coignac, Amelie</creatorcontrib><creatorcontrib>Aubry, Jean-Pierre</creatorcontrib><creatorcontrib>Lees, Rosemary K</creatorcontrib><creatorcontrib>Bonnefoy, Jean-Yves</creatorcontrib><creatorcontrib>MacDonald, H. Robson</creatorcontrib><creatorcontrib>Gauchat, Jean-Francois</creatorcontrib><title>A Role for CD147 in Thymic Development</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>We have previously identified a mAb that binds to a molecule expressed preferentially on the surface of cycling thymocytes. In this study the molecule recognized by this mAb has been identified in the mouse as CD147 (basigin) by expression cloning. We show that CD147 expression correlates with cycling of immature thymocytes even in the absence of TCRbeta selection and that ligation of this molecule on immature fetal thymocytes inhibits their further development into mature T cells.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antibodies, Monoclonal - metabolism</subject><subject>Antigens, CD</subject><subject>Antigens, Neoplasm</subject><subject>Antigens, Surface</subject><subject>Avian Proteins</subject><subject>Base Sequence</subject><subject>Basigin</subject><subject>Binding Sites, Antibody - genetics</subject><subject>Blood Proteins</subject><subject>Cell Cycle - genetics</subject><subject>Cell Cycle - immunology</subject><subject>Cell Differentiation - genetics</subject><subject>Cell Differentiation - immunology</subject><subject>Cell Line</subject><subject>Cloning, Molecular</subject><subject>Female</subject><subject>Fetus</subject><subject>Humans</subject><subject>Membrane Glycoproteins - biosynthesis</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Glycoproteins - immunology</subject><subject>Membrane Glycoproteins - physiology</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - immunology</subject><subject>Membrane Proteins - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Molecular Sequence Data</subject><subject>Organ Culture Techniques</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - biosynthesis</subject><subject>Thymus Gland - cytology</subject><subject>Thymus Gland - embryology</subject><subject>Thymus Gland - immunology</subject><subject>Thymus Gland - metabolism</subject><subject>Tumor Cells, Cultured</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1LwzAYh4Mobk7_A5GehpfON20-muPY_IKBIPMc0jR1GUk7m9Wy_97OTfTm6YWX5_ccHoSuMUwIEHG3tt63Ve0mmGWT_VMQdoKGmFKIGQN2ioYASRJjzvgAXYSwBgAGCTlHA4yFIITQIRpPo9famaism2g2x4RHtoqWq523OpqbT-PqjTfV9hKdlcoFc3W8I_T2cL-cPcWLl8fn2XQRa8LFNiY5wdqwxBSKaF4yxWnBqQahDKVJkWapZpgKCjlXZZGyBGdpzkELxXleapOO0Pjg3TT1R2vCVnobtHFOVaZug-SYMc5x8i_Yi0WacehBcgB1U4fQmFJuGutVs5MY5D6k_Akp-5Dfzz5kP7s5-tvcm-J3dCzXA7cHYGXfV51tjAxeOdfjWHZd99f1BebYfEI</recordid><startdate>20020515</startdate><enddate>20020515</enddate><creator>Renno, Toufic</creator><creator>Wilson, Anne</creator><creator>Dunkel, Caroline</creator><creator>Coste, Isabelle</creator><creator>Maisnier-Patin, Karine</creator><creator>Benoit de Coignac, Amelie</creator><creator>Aubry, Jean-Pierre</creator><creator>Lees, Rosemary K</creator><creator>Bonnefoy, Jean-Yves</creator><creator>MacDonald, H. Robson</creator><creator>Gauchat, Jean-Francois</creator><general>Am Assoc Immnol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20020515</creationdate><title>A Role for CD147 in Thymic Development</title><author>Renno, Toufic ; Wilson, Anne ; Dunkel, Caroline ; Coste, Isabelle ; Maisnier-Patin, Karine ; Benoit de Coignac, Amelie ; Aubry, Jean-Pierre ; Lees, Rosemary K ; Bonnefoy, Jean-Yves ; MacDonald, H. Robson ; Gauchat, Jean-Francois</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-4b41ce62eda4c7f6a75d75c09ae552d383c615950b7afd362183b70c9a77bfce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Antibodies, Monoclonal - metabolism</topic><topic>Antigens, CD</topic><topic>Antigens, Neoplasm</topic><topic>Antigens, Surface</topic><topic>Avian Proteins</topic><topic>Base Sequence</topic><topic>Basigin</topic><topic>Binding Sites, Antibody - genetics</topic><topic>Blood Proteins</topic><topic>Cell Cycle - genetics</topic><topic>Cell Cycle - immunology</topic><topic>Cell Differentiation - genetics</topic><topic>Cell Differentiation - immunology</topic><topic>Cell Line</topic><topic>Cloning, Molecular</topic><topic>Female</topic><topic>Fetus</topic><topic>Humans</topic><topic>Membrane Glycoproteins - biosynthesis</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Glycoproteins - immunology</topic><topic>Membrane Glycoproteins - physiology</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - immunology</topic><topic>Membrane Proteins - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Molecular Sequence Data</topic><topic>Organ Culture Techniques</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - biosynthesis</topic><topic>Thymus Gland - cytology</topic><topic>Thymus Gland - embryology</topic><topic>Thymus Gland - immunology</topic><topic>Thymus Gland - metabolism</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Renno, Toufic</creatorcontrib><creatorcontrib>Wilson, Anne</creatorcontrib><creatorcontrib>Dunkel, Caroline</creatorcontrib><creatorcontrib>Coste, Isabelle</creatorcontrib><creatorcontrib>Maisnier-Patin, Karine</creatorcontrib><creatorcontrib>Benoit de Coignac, Amelie</creatorcontrib><creatorcontrib>Aubry, Jean-Pierre</creatorcontrib><creatorcontrib>Lees, Rosemary K</creatorcontrib><creatorcontrib>Bonnefoy, Jean-Yves</creatorcontrib><creatorcontrib>MacDonald, H. 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Robson</au><au>Gauchat, Jean-Francois</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Role for CD147 in Thymic Development</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>2002-05-15</date><risdate>2002</risdate><volume>168</volume><issue>10</issue><spage>4946</spage><epage>4950</epage><pages>4946-4950</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>We have previously identified a mAb that binds to a molecule expressed preferentially on the surface of cycling thymocytes. In this study the molecule recognized by this mAb has been identified in the mouse as CD147 (basigin) by expression cloning. We show that CD147 expression correlates with cycling of immature thymocytes even in the absence of TCRbeta selection and that ligation of this molecule on immature fetal thymocytes inhibits their further development into mature T cells.</abstract><cop>United States</cop><pub>Am Assoc Immnol</pub><pmid>11994445</pmid><doi>10.4049/jimmunol.168.10.4946</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1767 |
| ispartof | The Journal of immunology (1950), 2002-05, Vol.168 (10), p.4946-4950 |
| issn | 0022-1767 1550-6606 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Animals Antibodies, Monoclonal - metabolism Antigens, CD Antigens, Neoplasm Antigens, Surface Avian Proteins Base Sequence Basigin Binding Sites, Antibody - genetics Blood Proteins Cell Cycle - genetics Cell Cycle - immunology Cell Differentiation - genetics Cell Differentiation - immunology Cell Line Cloning, Molecular Female Fetus Humans Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Membrane Glycoproteins - immunology Membrane Glycoproteins - physiology Membrane Proteins - genetics Membrane Proteins - immunology Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Molecular Sequence Data Organ Culture Techniques Receptors, Antigen, T-Cell, alpha-beta - biosynthesis Thymus Gland - cytology Thymus Gland - embryology Thymus Gland - immunology Thymus Gland - metabolism Tumor Cells, Cultured |
| title | A Role for CD147 in Thymic Development |
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