A Role for CD147 in Thymic Development

We have previously identified a mAb that binds to a molecule expressed preferentially on the surface of cycling thymocytes. In this study the molecule recognized by this mAb has been identified in the mouse as CD147 (basigin) by expression cloning. We show that CD147 expression correlates with cycli...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2002-05, Vol.168 (10), p.4946-4950
Hauptverfasser:	Renno, Toufic, Wilson, Anne, Dunkel, Caroline, Coste, Isabelle, Maisnier-Patin, Karine, Benoit de Coignac, Amelie, Aubry, Jean-Pierre, Lees, Rosemary K, Bonnefoy, Jean-Yves, MacDonald, H. Robson, Gauchat, Jean-Francois
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Monoclonal - metabolism Antigens, CD Antigens, Neoplasm Antigens, Surface Avian Proteins Base Sequence Basigin Binding Sites, Antibody - genetics Blood Proteins Cell Cycle - genetics Cell Cycle - immunology Cell Differentiation - genetics Cell Differentiation - immunology Cell Line Cloning, Molecular Female Fetus Humans Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Membrane Glycoproteins - immunology Membrane Glycoproteins - physiology Membrane Proteins - genetics Membrane Proteins - immunology Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Molecular Sequence Data Organ Culture Techniques Receptors, Antigen, T-Cell, alpha-beta - biosynthesis Thymus Gland - cytology Thymus Gland - embryology Thymus Gland - immunology Thymus Gland - metabolism Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We have previously identified a mAb that binds to a molecule expressed preferentially on the surface of cycling thymocytes. In this study the molecule recognized by this mAb has been identified in the mouse as CD147 (basigin) by expression cloning. We show that CD147 expression correlates with cycling of immature thymocytes even in the absence of TCRbeta selection and that ligation of this molecule on immature fetal thymocytes inhibits their further development into mature T cells.
ISSN:	0022-1767 1550-6606
DOI:	10.4049/jimmunol.168.10.4946