Protective role of cyclooxygenase (COX) inhibitors in burn-induced intestinal and liver damage

The aim of this study was to investigate the role of cyclooxygenase (COX) inhibition in intestinal motility and in the extent of tissue injury of the small intestine and liver with the use of various COX inhibitors. Wistar albino rats were exposed to 90 °C water bath for 10 s. The intestinal transit...

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Veröffentlicht in:	Burns 2002-05, Vol.28 (3), p.209-214
Hauptverfasser:	Oktar, Berna K., Çakir, Barış, Mutlu, Nilgün, Çelikel, Çiǧdem, Alican, İnci
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Burn Burns Cyclooxygenase Cyclooxygenase Inhibitors - pharmacology Cyclooxygenase Inhibitors - therapeutic use Gastrointestinal Motility - drug effects Glutathione - analysis Intestinal motility Intestinal Mucosa - metabolism Intestines - drug effects Intestines - injuries Lipid Peroxidation Liver - drug effects Liver - injuries Liver - metabolism Liver Function Tests Medical sciences Neutrophils Oxidant damage Peroxidase - analysis Rats Rats, Wistar Traumas. Diseases due to physical agents Tropical medicine
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Zusammenfassung:	The aim of this study was to investigate the role of cyclooxygenase (COX) inhibition in intestinal motility and in the extent of tissue injury of the small intestine and liver with the use of various COX inhibitors. Wistar albino rats were exposed to 90 °C water bath for 10 s. The intestinal transit index decreased compared to control group and treatment with nimesulide (NIM; 10 mg/kg, subcutaneously) or piroxicam (Pir; 5 mg/kg, orogastrically) reversed this effect significantly. The intestinal and liver glutathione levels showed a significant decrease in the burn group compared to sham ( P
ISSN:	0305-4179 1879-1409
DOI:	10.1016/S0305-4179(02)00004-9