Natural trans-Crotonin: The Antiulcerogenic Effect of Another Diterpene Isolated from the Bark of Croton cajucara BENTH

The nor-clerodane diterpene trans-crotonin isolated from the bark of Croton cajucara BENTH. was investigated for its ability to prevent the formation of gastric-mucosa ulceration in different experimental models in mice. The results obtained from crotonin were compared with those obtained with anoth...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2002, Vol.25(4), pp.452-456
Hauptverfasser:	Hiruma-Lima, Clélia Akiko, Toma, Walber, Gracioso, Juliano de Souza, Ana Beatriz Albino de Almeida, Batista, Leônia Maria, Magri, Luciana, Ana Cláudia Bensuaski de Paula, Soares, Fernanda Rocha, Nunes, Domingos Sávio, Alba Regina Monteiro Souza Brito
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Ulcer Agents - chemistry Anti-Ulcer Agents - isolation & purification Anti-Ulcer Agents - therapeutic use Biological and medical sciences Croton - chemistry Croton cajucara crotonin DHC Digestive system diterpene Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - therapeutic use Diterpenes, Clerodane Euphorbiaceae gastroprotective activity Male Medical sciences Mice Pharmacology. Drug treatments Plant Bark - chemistry Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - therapeutic use Stomach Ulcer - drug therapy
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Zusammenfassung:	The nor-clerodane diterpene trans-crotonin isolated from the bark of Croton cajucara BENTH. was investigated for its ability to prevent the formation of gastric-mucosa ulceration in different experimental models in mice. The results obtained from crotonin were compared with those obtained with another diterpene, DHC (trans-dehydrocrotonin) in the same models. When previously administered (p.o.) at the dose of 100 mg/kg, crotonin, as well as DHC, significantly reduced (p
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.25.452