Genes regulating the serotonin metabolic pathway in the brain stem and their role in the etiopathogenesis of the sudden infant death syndrome

Genotypes and allelic frequencies of TPH2, 5-HTTLPR, the 5-HTT ( SLC6A4) intron 2 variable-number tandem repeat (VNTR) region, and the MAOA VNTR region were determined in brain-stem samples of 20 “genuine” SIDS cases and compared with results obtained from 150 healthy controls. The SNP G1463A respon...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 2008-06, Vol.91 (6), p.485-491
Hauptverfasser:	Nonnis Marzano, Francesco, Maldini, Milena, Filonzi, Laura, Lavezzi, Anna Maria, Parmigiani, Stefano, Magnani, Cinzia, Bevilacqua, Giulio, Matturri, Luigi
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HTT Biological and medical sciences Brain Stem - metabolism Ethnic Groups - genetics Female Fundamental and applied biological sciences. Psychology Genes. Genome Genetics of eukaryotes. Biological and molecular evolution Humans Infant Italy Male MAOA Molecular and cellular biology Molecular genetics Molecular polymorphisms Monoamine Oxidase - genetics Monoamine Oxidase - physiology Neurotransmitter Polymorphism, Single Nucleotide Promoter Regions, Genetic Serotonin - metabolism Serotonin Plasma Membrane Transport Proteins - genetics Serotonin Plasma Membrane Transport Proteins - physiology SIDS Sudden Infant Death - genetics TPH2 Tryptophan Hydroxylase - genetics Tryptophan Hydroxylase - physiology
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