Outbreak of OXY-2-Producing Klebsiella oxytoca in a Renal Transplant Unit
We describe a Klebsiella oxytoca infection outbreak in a renal transplant unit that involved seven patients. All strains belonged to a single pulsed-field gel electrophoresis pattern and were resistant to amoxicillin-clavulanate, cefuroxime, piperacillin-tazobactam, and aztreonam but susceptible to...
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| Veröffentlicht in: | Journal of Clinical Microbiology 2008-06, Vol.46 (6), p.2099-2101 |
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| container_issue | 6 |
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| container_title | Journal of Clinical Microbiology |
| container_volume | 46 |
| creator | Zárate, Mariela Soledad Gales, Ana C Picão, Renata C Pujol, Gervasio Soler Lanza, Alejandra Smayevsky, Jorgelina |
| description | We describe a Klebsiella oxytoca infection outbreak in a renal transplant unit that involved seven patients. All strains belonged to a single pulsed-field gel electrophoresis pattern and were resistant to amoxicillin-clavulanate, cefuroxime, piperacillin-tazobactam, and aztreonam but susceptible to ceftriaxone, ceftazidime, cefepime, and imipenem. Chromosomal β-lactamase hyperproduction was caused by a point mutation in the blaOXY₋₂ gene promoter region. |
| doi_str_mv | 10.1128/JCM.00194-08 |
| format | Article |
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All strains belonged to a single pulsed-field gel electrophoresis pattern and were resistant to amoxicillin-clavulanate, cefuroxime, piperacillin-tazobactam, and aztreonam but susceptible to ceftriaxone, ceftazidime, cefepime, and imipenem. Chromosomal β-lactamase hyperproduction was caused by a point mutation in the blaOXY₋₂ gene promoter region.</description><identifier>ISSN: 0095-1137</identifier><identifier>EISSN: 1098-660X</identifier><identifier>EISSN: 1098-5530</identifier><identifier>DOI: 10.1128/JCM.00194-08</identifier><identifier>PMID: 18417660</identifier><identifier>CODEN: JCMIDW</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Anti-Bacterial Agents - pharmacology ; Bacteriology ; beta-Lactam Resistance ; beta-Lactamases - genetics ; beta-Lactamases - metabolism ; Biological and medical sciences ; Disease Outbreaks ; Electrophoresis, Gel, Pulsed-Field ; Epidemiology ; Fundamental and applied biological sciences. Psychology ; Hospital Units ; Humans ; Kidney Transplantation ; Klebsiella Infections - epidemiology ; Klebsiella Infections - microbiology ; Klebsiella oxytoca ; Klebsiella oxytoca - classification ; Klebsiella oxytoca - drug effects ; Klebsiella oxytoca - enzymology ; Klebsiella oxytoca - genetics ; Microbial Sensitivity Tests ; Microbiology ; Miscellaneous ; Point Mutation ; Promoter Regions, Genetic</subject><ispartof>Journal of Clinical Microbiology, 2008-06, Vol.46 (6), p.2099-2101</ispartof><rights>2008 INIST-CNRS</rights><rights>Copyright © 2008, American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-2fb099354d35718d9d1150cad27035bb78b699df2867b55cf3098abd030497f83</citedby><cites>FETCH-LOGICAL-c493t-2fb099354d35718d9d1150cad27035bb78b699df2867b55cf3098abd030497f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2446844/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2446844/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,3175,3176,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20419420$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18417660$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zárate, Mariela Soledad</creatorcontrib><creatorcontrib>Gales, Ana C</creatorcontrib><creatorcontrib>Picão, Renata C</creatorcontrib><creatorcontrib>Pujol, Gervasio Soler</creatorcontrib><creatorcontrib>Lanza, Alejandra</creatorcontrib><creatorcontrib>Smayevsky, Jorgelina</creatorcontrib><title>Outbreak of OXY-2-Producing Klebsiella oxytoca in a Renal Transplant Unit</title><title>Journal of Clinical Microbiology</title><addtitle>J Clin Microbiol</addtitle><description>We describe a Klebsiella oxytoca infection outbreak in a renal transplant unit that involved seven patients. All strains belonged to a single pulsed-field gel electrophoresis pattern and were resistant to amoxicillin-clavulanate, cefuroxime, piperacillin-tazobactam, and aztreonam but susceptible to ceftriaxone, ceftazidime, cefepime, and imipenem. Chromosomal β-lactamase hyperproduction was caused by a point mutation in the blaOXY₋₂ gene promoter region.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacteriology</subject><subject>beta-Lactam Resistance</subject><subject>beta-Lactamases - genetics</subject><subject>beta-Lactamases - metabolism</subject><subject>Biological and medical sciences</subject><subject>Disease Outbreaks</subject><subject>Electrophoresis, Gel, Pulsed-Field</subject><subject>Epidemiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hospital Units</subject><subject>Humans</subject><subject>Kidney Transplantation</subject><subject>Klebsiella Infections - epidemiology</subject><subject>Klebsiella Infections - microbiology</subject><subject>Klebsiella oxytoca</subject><subject>Klebsiella oxytoca - classification</subject><subject>Klebsiella oxytoca - drug effects</subject><subject>Klebsiella oxytoca - enzymology</subject><subject>Klebsiella oxytoca - genetics</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Point Mutation</subject><subject>Promoter Regions, Genetic</subject><issn>0095-1137</issn><issn>1098-660X</issn><issn>1098-5530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0s1v0zAYBnALgVhXuHGGcBgnMl5_JfYFCVUwBkNFsErjZDmO03pL4mInbPvv59BqwImTD_7pkd_3MULPMBxjTMSbT4svxwBYshzEAzTDIEVeFHDxEM0AJM8xpuUBOozxMinGOH-MDrBguExohk6X41AFq68y32TLix85yb8GX4_G9evsc2ur6Gzb6szf3A7e6Mz1mc6-2V632XnQfdy2uh-yVe-GJ-hRo9ton-7POVp9eH---JifLU9OF-_OcsMkHXLSVCAl5aymvMSiljXGHIyuSQmUV1UpqkLKuiGiKCvOTUPTQLqqgQKTZSPoHL3d5W7HqrO1sf0QdKu2wXU63Cqvnfr3pncbtfa_FGGsEIylgFf7gOB_jjYOqnPRTFP21o9RlbjgaXPkv5CAIJSx6Umvd9AEH2Owzf1rMKipJJVKUr9LUjDx539P8AfvW0ngaA90NLpt0qKNi_eOAEtJZHIvd27j1ptrF6zSsVOXplOsUEVyadFz9GJnGu2VXoeUs_pOANM0ItD0W-gdHRyszA</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>Zárate, Mariela Soledad</creator><creator>Gales, Ana C</creator><creator>Picão, Renata C</creator><creator>Pujol, Gervasio Soler</creator><creator>Lanza, Alejandra</creator><creator>Smayevsky, Jorgelina</creator><general>American Society for Microbiology</general><general>American Society for Microbiology (ASM)</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080601</creationdate><title>Outbreak of OXY-2-Producing Klebsiella oxytoca in a Renal Transplant Unit</title><author>Zárate, Mariela Soledad ; Gales, Ana C ; Picão, Renata C ; Pujol, Gervasio Soler ; Lanza, Alejandra ; Smayevsky, Jorgelina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-2fb099354d35718d9d1150cad27035bb78b699df2867b55cf3098abd030497f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacteriology</topic><topic>beta-Lactam Resistance</topic><topic>beta-Lactamases - genetics</topic><topic>beta-Lactamases - metabolism</topic><topic>Biological and medical sciences</topic><topic>Disease Outbreaks</topic><topic>Electrophoresis, Gel, Pulsed-Field</topic><topic>Epidemiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hospital Units</topic><topic>Humans</topic><topic>Kidney Transplantation</topic><topic>Klebsiella Infections - epidemiology</topic><topic>Klebsiella Infections - microbiology</topic><topic>Klebsiella oxytoca</topic><topic>Klebsiella oxytoca - classification</topic><topic>Klebsiella oxytoca - drug effects</topic><topic>Klebsiella oxytoca - enzymology</topic><topic>Klebsiella oxytoca - genetics</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Point Mutation</topic><topic>Promoter Regions, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zárate, Mariela Soledad</creatorcontrib><creatorcontrib>Gales, Ana C</creatorcontrib><creatorcontrib>Picão, Renata C</creatorcontrib><creatorcontrib>Pujol, Gervasio Soler</creatorcontrib><creatorcontrib>Lanza, Alejandra</creatorcontrib><creatorcontrib>Smayevsky, Jorgelina</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Clinical Microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zárate, Mariela Soledad</au><au>Gales, Ana C</au><au>Picão, Renata C</au><au>Pujol, Gervasio Soler</au><au>Lanza, Alejandra</au><au>Smayevsky, Jorgelina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outbreak of OXY-2-Producing Klebsiella oxytoca in a Renal Transplant Unit</atitle><jtitle>Journal of Clinical Microbiology</jtitle><addtitle>J Clin Microbiol</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>46</volume><issue>6</issue><spage>2099</spage><epage>2101</epage><pages>2099-2101</pages><issn>0095-1137</issn><eissn>1098-660X</eissn><eissn>1098-5530</eissn><coden>JCMIDW</coden><abstract>We describe a Klebsiella oxytoca infection outbreak in a renal transplant unit that involved seven patients. All strains belonged to a single pulsed-field gel electrophoresis pattern and were resistant to amoxicillin-clavulanate, cefuroxime, piperacillin-tazobactam, and aztreonam but susceptible to ceftriaxone, ceftazidime, cefepime, and imipenem. Chromosomal β-lactamase hyperproduction was caused by a point mutation in the blaOXY₋₂ gene promoter region.</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>18417660</pmid><doi>10.1128/JCM.00194-08</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | American Society for Microbiology; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Anti-Bacterial Agents - pharmacology Bacteriology beta-Lactam Resistance beta-Lactamases - genetics beta-Lactamases - metabolism Biological and medical sciences Disease Outbreaks Electrophoresis, Gel, Pulsed-Field Epidemiology Fundamental and applied biological sciences. Psychology Hospital Units Humans Kidney Transplantation Klebsiella Infections - epidemiology Klebsiella Infections - microbiology Klebsiella oxytoca Klebsiella oxytoca - classification Klebsiella oxytoca - drug effects Klebsiella oxytoca - enzymology Klebsiella oxytoca - genetics Microbial Sensitivity Tests Microbiology Miscellaneous Point Mutation Promoter Regions, Genetic |
| title | Outbreak of OXY-2-Producing Klebsiella oxytoca in a Renal Transplant Unit |
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