Outbreak of OXY-2-Producing Klebsiella oxytoca in a Renal Transplant Unit

We describe a Klebsiella oxytoca infection outbreak in a renal transplant unit that involved seven patients. All strains belonged to a single pulsed-field gel electrophoresis pattern and were resistant to amoxicillin-clavulanate, cefuroxime, piperacillin-tazobactam, and aztreonam but susceptible to...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of Clinical Microbiology 2008-06, Vol.46 (6), p.2099-2101
Hauptverfasser:	Zárate, Mariela Soledad, Gales, Ana C, Picão, Renata C, Pujol, Gervasio Soler, Lanza, Alejandra, Smayevsky, Jorgelina
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Bacteriology beta-Lactam Resistance beta-Lactamases - genetics beta-Lactamases - metabolism Biological and medical sciences Disease Outbreaks Electrophoresis, Gel, Pulsed-Field Epidemiology Fundamental and applied biological sciences. Psychology Hospital Units Humans Kidney Transplantation Klebsiella Infections - epidemiology Klebsiella Infections - microbiology Klebsiella oxytoca Klebsiella oxytoca - classification Klebsiella oxytoca - drug effects Klebsiella oxytoca - enzymology Klebsiella oxytoca - genetics Microbial Sensitivity Tests Microbiology Miscellaneous Point Mutation Promoter Regions, Genetic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We describe a Klebsiella oxytoca infection outbreak in a renal transplant unit that involved seven patients. All strains belonged to a single pulsed-field gel electrophoresis pattern and were resistant to amoxicillin-clavulanate, cefuroxime, piperacillin-tazobactam, and aztreonam but susceptible to ceftriaxone, ceftazidime, cefepime, and imipenem. Chromosomal β-lactamase hyperproduction was caused by a point mutation in the blaOXY₋₂ gene promoter region.
ISSN:	0095-1137 1098-660X 1098-5530
DOI:	10.1128/JCM.00194-08