SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-δ

Obesity and metabolic syndrome are increasingly recognized as major risk factors for cardiovascular disease. Herein we show that Krüppel-like transcription factor 5 (KLF5) is a crucial regulator of energy metabolism. Klf5 +/− mice were resistant to high fat–induced obesity, hypercholesterolemia and...

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Veröffentlicht in:	Nature medicine 2008-06, Vol.14 (6), p.656-666
Hauptverfasser:	Manabe, Ichiro, Nagai, Ryozo, Oishi, Yumiko, Tobe, Kazuyuki, Ohsugi, Mitsuru, Kubota, Tetsuya, Fujiu, Katsuhito, Maemura, Koji, Kubota, Naoto, Kadowaki, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Body Temperature Cancer Research Cardiovascular diseases Cell Line Cercopithecus aethiops Cholesterol - blood Complications and side effects COS Cells Crosses, Genetic DNA binding proteins Genes, Reporter Genetic aspects Glucose Tolerance Test Health aspects Heterozygote Infectious Diseases Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Leptin - blood Lipid Metabolism Luciferases - metabolism Metabolic Diseases Mice Mice, Inbred C57BL Mice, Knockout Molecular Medicine Mutation Myoblasts - cytology Myoblasts - metabolism Neurosciences Obesity Oxygen Consumption Physiological aspects PPAR delta - genetics PPAR delta - metabolism Risk factors Small Ubiquitin-Related Modifier Proteins - metabolism Transcription, Genetic
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