Altered Editing of Serotonin 2C Receptor Pre-mRNA in the Prefrontal Cortex of Depressed Suicide Victims

Five adenosines within the coding sequence of the serotonin 2C receptor (5-HT2C) pre-mRNA are converted to inosines by RNA editing (named A, B, C′ (E), C, and D sites). In human prefrontal cortex (PFC), the most abundant 5-HT2C mRNA sequences result from editing at the A site, or from the editing co...

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Veröffentlicht in:Neuron (Cambridge, Mass.) Mass.), 2002-04, Vol.34 (3), p.349-356
Hauptverfasser: Gurevich, Ilona, Tamir, Hadassah, Arango, Victoria, Dwork, Andrew J., Mann, J.John, Schmauss, Claudia
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Sprache:eng
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Zusammenfassung:Five adenosines within the coding sequence of the serotonin 2C receptor (5-HT2C) pre-mRNA are converted to inosines by RNA editing (named A, B, C′ (E), C, and D sites). In human prefrontal cortex (PFC), the most abundant 5-HT2C mRNA sequences result from editing at the A site, or from the editing combinations AC′C, ABCD, and ABD. In suicide victims with a history of major depression, C′ site editing is significantly increased, D site editing is significantly decreased, and the C site shows a trend toward increased editing. Treatment of mice with the antidepressant drug fluoxetine (Prozac™) causes changes in C′, C, and D site editing that are exactly opposite to those seen in suicide victims. Thus, one outcome of fluoxetine treatment may be to reverse the abnormalities in 5-HT2C pre-mRNA editing seen in depressed suicide victims.
ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(02)00660-8