WNT Signaling and Lymphocyte Development

Developmental studies in model organisms have revealed that cell fate decisions are governed by only a handful of highly conserved signal transduction cascades. Recent data indicate that at least two of these, the Wnt and the Notch cascades, have been recruited by the vertebrate immune system to con...

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Veröffentlicht in:	Cell 2002-04, Vol.109 (2), p.S13-S19
Hauptverfasser:	van de Wetering, Marc, de Lau, Wim, Clevers, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cell Lineage DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Humans Lymphocytes - cytology Lymphocytes - metabolism Lymphoid Enhancer-Binding Factor 1 Mice Mice, Knockout Proto-Oncogene Proteins - metabolism Signal Transduction Thymus Gland - cytology Thymus Gland - metabolism Transcription Factors - genetics Transcription Factors - metabolism Wnt Proteins Zebrafish Proteins
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Beschreibung
Zusammenfassung:	Developmental studies in model organisms have revealed that cell fate decisions are governed by only a handful of highly conserved signal transduction cascades. Recent data indicate that at least two of these, the Wnt and the Notch cascades, have been recruited by the vertebrate immune system to control early lymphopoiesis.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/S0092-8674(02)00709-2