Soft tissue uptake of Tc99m-MDP in acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is associated rarely with hypercalcemia. This may be due to elevated levels of parathyroid hormone-related peptide (PTHrP). We report a case of an 18-year-old female patient who was presented with a pathological fracture of left intertrochanteric region. Bone scint...

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Veröffentlicht in:	Clinical imaging 2002-05, Vol.26 (3), p.206-208
Hauptverfasser:	Marwah, Atul, Kumar, Rakesh, Dasan J, Bharathi, Choudhury, Saikat, Bandopadhyaya, Gurupad, Malhotra, Arun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Adolescent Biological and medical sciences Bone scintigraphy Female Hematologic and hematopoietic diseases Humans Hypercalcemia Hypercalcemia - blood Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnostic imaging Radionuclide Imaging Radiopharmaceuticals Soft tissue uptake Tc99m-MDP Technetium Tc 99m Medronate Whole-Body Counting
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Zusammenfassung:	Acute lymphoblastic leukemia (ALL) is associated rarely with hypercalcemia. This may be due to elevated levels of parathyroid hormone-related peptide (PTHrP). We report a case of an 18-year-old female patient who was presented with a pathological fracture of left intertrochanteric region. Bone scintigraphy was consistent with features of hypercalcemia associated with metastatic calcification. A bone marrow biopsy led to the diagnosis of ALL. The mechanism of hypercalcemia in ALL, metastatic calcification and soft tissue uptake of bone seeking agents in this case are discussed in detail.
ISSN:	0899-7071 1873-4499
DOI:	10.1016/S0899-7071(01)00384-9