Serum levels of S100B are decreased in chronic starvation and normalize with weight gain

S100B protein is mainly synthesized in glial cells and modulates the balance between cell proliferation and differentiation in neurons and glial cells. However, S100B is not CNS-specific since its production was detected in numerous non-cerebral tissues e.g. adipocytes. In this study we investigated...

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Veröffentlicht in:	Journal of Neural Transmission 2008-06, Vol.115 (6), p.937-940
Hauptverfasser:	Holtkamp, Kristian, Bühren, Katharina, Ponath, Gerald, von Eiff, Christoph, Herpertz-Dahlmann, Beate, Hebebrand, Johannes, Rothermundt, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age Factors Anorexia Nervosa - blood Anorexia Nervosa - complications Anorexia Nervosa - diet therapy Biological Child and Adolescent Psychiatry - Short Communication Biomarkers - analysis Biomarkers - blood Body Composition Body Mass Index Chronic Disease Dietary Proteins Down-Regulation - physiology Female Humans Leptin - blood Medicine Medicine & Public Health Nerve Growth Factors - blood Neurology Neurosciences Nutritional Status Predictive Value of Tests Psychiatry Recovery of Function - physiology Reference Values S100 Calcium Binding Protein beta Subunit S100 Proteins - blood Starvation - blood Starvation - complications Starvation - diet therapy Weight Gain - physiology
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Zusammenfassung:	S100B protein is mainly synthesized in glial cells and modulates the balance between cell proliferation and differentiation in neurons and glial cells. However, S100B is not CNS-specific since its production was detected in numerous non-cerebral tissues e.g. adipocytes. In this study we investigated the influence of chronic fasting and subsequent weight gain on serum levels of S100B in patients with anorexia nervosa. We found that nutritional status was an important factor influencing serum levels of S100B.
ISSN:	0300-9564 1435-1463
DOI:	10.1007/s00702-008-0041-8