Analysis of CYP3A inhibitory components of star fruit (Averrhoa carambola L.) using liquid chromatography–mass spectrometry

In this study, we analyzed the CYP3A inhibitory components of star fruit Averrhoa carambola L., using liquid chromatography–mass spectrometry (LC–MS). The stereoisomer of procyanidin B1 and B2 and/or the trimer consisting of catechin and/or epicatechin were suggested to be potent inhibitory componen...

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Veröffentlicht in:	Journal of natural medicines 2008-07, Vol.62 (3), p.345-348
Hauptverfasser:	Hosoi, Shinzo, Shimizu, Eri, Arimori, Kazuhiko, Okumura, Manabu, Hidaka, Muneaki, Yamada, Mitsuko, Sakushima, Akiyo
Format:	Artikel
Sprache:	eng
Schlagworte:	Biflavonoids - isolation & purification Biflavonoids - pharmacology Biomedical and Life Sciences Biomedicine Catechin - isolation & purification Catechin - pharmacology Chromatography, Liquid Complementary & Alternative Medicine Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme Inhibitors Fruit Humans In Vitro Techniques Magnoliopsida - chemistry Mass Spectrometry Medicinal Chemistry Microsomes, Liver - enzymology Microsomes, Liver - metabolism Pharmacology/Toxicology Pharmacy Plant Extracts - chemistry Plant Extracts - pharmacology Plant Sciences Proanthocyanidins - isolation & purification Proanthocyanidins - pharmacology Stereoisomerism
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Zusammenfassung:	In this study, we analyzed the CYP3A inhibitory components of star fruit Averrhoa carambola L., using liquid chromatography–mass spectrometry (LC–MS). The stereoisomer of procyanidin B1 and B2 and/or the trimer consisting of catechin and/or epicatechin were suggested to be potent inhibitory components.
ISSN:	1340-3443 1861-0293
DOI:	10.1007/s11418-008-0239-y