Hemolytic uremic syndrome due to an altered factor H triggered by neonatal pertussis

We report on a previously healthy newborn suffering from severe Bordetella pertussis infection who developed hemolytic uremic syndrome (HUS) a few weeks after the onset of whooping cough, with a fatal outcome. A factor H protein with abnormal mobility was found in the serum of the patient as analyze...

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Veröffentlicht in:	Pediatric nephrology (Berlin, West) West), 2002-03, Vol.17 (3), p.190-192
Hauptverfasser:	BERNER, Reinhard, KRAUSE, Martin F, GORDJANI, Nader, ZIPFEL, Peter F, BOEHM, Norbert, KRUEGER, Marcus, BRANDIS, Matthias, ZIMMERHACKL, Lothar B
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bordetella pertussis Complement Factor H - metabolism Hemolytic-Uremic Syndrome - etiology Humans Infant, Newborn Male Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Renal failure Whooping Cough - complications Whooping Cough - immunology
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Beschreibung
Zusammenfassung:	We report on a previously healthy newborn suffering from severe Bordetella pertussis infection who developed hemolytic uremic syndrome (HUS) a few weeks after the onset of whooping cough, with a fatal outcome. A factor H protein with abnormal mobility was found in the serum of the patient as analyzed by Western blotting, indicating that B. pertussis infection might have triggered HUS in a genetically predisposed patient.
ISSN:	0931-041X 1432-198X
DOI:	10.1007/s00467-001-0798-6